SLC22A7

From Wikipedia, the free encyclopedia

Solute carrier family 22 (organic anion transporter), member 7

Identifiers

SLC22A7; MGC24091; MGC45202; NLT; OAT2

External IDs

OMIM: 604995 MGI: 1859559 HomoloGene: 21328

Gene ontology
Molecular Function:	• nucleotide binding • transporter activity • ATP binding • ion transmembrane transporter activity • symporter activity • sodium-independent organic anion transmembrane transporter activity • sodium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane • integral to membrane
Biological Process:	• transport • ion transport • sodium ion transport • organic anion transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006672 (mRNA)
NP_006663 (protein)

XM_001002761 (mRNA)
XP_001002761 (protein)

Location

Chr 6: 43.37 - 43.38 Mb

Chr 17: 45.9 - 45.9 Mb

Pubmed search

[1]

[2]

Solute carrier family 22 (organic anion transporter), member 7, also known as SLC22A7, is a human gene.^[1]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.^[1]

[edit] See also

MeSH SLC22A7+protein,+human

[edit] References

^ ^a ^b Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7.

[edit] Further reading

Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.". Mol. Pharmacol. 73 (4): 1151-8. doi:10.1124/mol.107.043117. PMID 18216183.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.". J. Pharmacol. Exp. Ther. 301 (3): 797-802. PMID 12023506.
Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.". J. Pharmacol. Exp. Ther. 301 (1): 293-8. PMID 11907186.
Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline.". Jpn. J. Pharmacol. 88 (1): 69-76. PMID 11855680.
Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney.". Biochem. Biophys. Res. Commun. 283 (2): 417-22. doi:10.1006/bbrc.2001.4774. PMID 11327718.
Kok LD, Siu SS, Fung KP, et al. (2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2-->p21.1 using radiation hybrids.". Cytogenet. Cell Genet. 88 (1-2): 76-7. PMID 10773670.
Sekine T, Cha SH, Tsuda M, et al. (1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver.". FEBS Lett. 429 (2): 179-82. PMID 9650585.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)