SLC22A6

From Wikipedia, the free encyclopedia

Solute carrier family 22 (organic anion transporter), member 6

Identifiers

SLC22A6; OAT1; HOAT1; MGC45260; PAHT; ROAT1

External IDs

OMIM: 607582 MGI: 892001 HomoloGene: 16813

Gene ontology
Molecular Function:	• nucleotide binding • ATP binding • organic anion transmembrane transporter activity • ion transmembrane transporter activity • symporter activity • sodium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane • integral to membrane
Biological Process:	• ion transport • sodium ion transport • organic anion transport • alpha-ketoglutarate transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004790 (mRNA)
NP_004781 (protein)

NM_008766 (mRNA)
NP_032792 (protein)

Location

Chr 11: 62.5 - 62.51 Mb

Chr 19: 8.69 - 8.7 Mb

Pubmed search

[1]

[2]

Solute carrier family 22 (organic anion transporter), member 6, also known as SLC22A6, is a human gene.^[1]

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Five transcript variants encoding five different isoforms have been found for this gene.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC22A6 solute carrier family 22 (organic anion transporter), member 6.

[edit] Further reading

Reid G, Wolff NA, Dautzenberg FM, Burckhardt G (1999). "Cloning of a human renal p-aminohippurate transporter, hROAT1.". Kidney Blood Press. Res. 21 (2-4): 233–7. PMID 9762842.
Hosoyamada M, Sekine T, Kanai Y, Endou H (1999). "Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.". Am. J. Physiol. 276 (1 Pt 2): F122–8. PMID 9887087.
Lu R, Chan BS, Schuster VL (1999). "Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.". Am. J. Physiol. 276 (2 Pt 2): F295–303. PMID 9950961.
Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).". Biochem. Biophys. Res. Commun. 255 (2): 508–14. doi:10.1006/bbrc.1998.9978. PMID 10049739.
Cihlar T, Lin DC, Pritchard JB, et al. (1999). "The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.". Mol. Pharmacol. 56 (3): 570–80. PMID 10462545.
Bahn A, Prawitt D, Buttler D, et al. (2000). "Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.". Biochem. Biophys. Res. Commun. 275 (2): 623–30. doi:10.1006/bbrc.2000.3230. PMID 10964714.
Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline.". Jpn. J. Pharmacol. 88 (1): 69–76. PMID 11855680.
Burckhardt BC, Brai S, Wallis S, et al. (2003). "Transport of cimetidine by flounder and human renal organic anion transporter 1.". Am. J. Physiol. Renal Physiol. 284 (3): F503–9. doi:10.1152/ajprenal.00290.2002. PMID 12429554.
Ichida K, Hosoyamada M, Kimura H, et al. (2004). "Urate transport via human PAH transporter hOAT1 and its gene structure.". Kidney Int. 63 (1): 143–55. doi:10.1046/j.1523-1755.2003.00710.x. PMID 12472777.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wolff NA, Thies K, Kuhnke N, et al. (2004). "Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization.". J. Am. Soc. Nephrol. 14 (8): 1959–68. PMID 12874449.
Sauvant C, Hesse D, Holzinger H, et al. (2004). "Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells.". Am. J. Physiol. Renal Physiol. 286 (4): F774–83. doi:10.1152/ajprenal.00326.2003. PMID 14644751.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tanaka K, Xu W, Zhou F, You G (2004). "Role of glycosylation in the organic anion transporter OAT1.". J. Biol. Chem. 279 (15): 14961–6. doi:10.1074/jbc.M400197200. PMID 14749323.
Sakurai Y, Motohashi H, Ueo H, et al. (2004). "Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases.". Pharm. Res. 21 (1): 61–7. PMID 14984259.
Bahn A, Ebbinghaus C, Ebbinghaus D, et al. (2005). "Expression studies and functional characterization of renal human organic anion transporter 1 isoforms.". Drug Metab. Dispos. 32 (4): 424–30. doi:10.1124/dmd.32.4.424. PMID 15039295.
Hong M, Zhou F, You G (2004). "Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.". J. Biol. Chem. 279 (30): 31478–82. doi:10.1074/jbc.M404686200. PMID 15145940.
Zalups RK, Aslamkhan AG, Ahmad S (2005). "Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury.". Kidney Int. 66 (1): 251–61. doi:10.1111/j.1523-1755.2004.00726.x. PMID 15200431.
Zalups RK, Ahmad S (2004). "Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1.". J. Am. Soc. Nephrol. 15 (8): 2023–31. doi:10.1097/01.ASN.0000135115.63412.A9. PMID 15284288.
Fujita T, Brown C, Carlson EJ, et al. (2005). "Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).". Pharmacogenet. Genomics 15 (4): 201–9. PMID 15864112.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)