SLC22A4

From Wikipedia, the free encyclopedia

Solute carrier family 22 (organic cation transporter), member 4

Identifiers

SLC22A4; MGC34546; MGC40524; OCTN1

External IDs

OMIM: 604190 MGI: 1353479 HomoloGene: 81701

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • ATP binding • secondary active organic cation transmembrane transporter activity • ion transmembrane transporter activity • symporter activity • sodium ion binding
Cellular Component:	• nucleosome • nucleus • mitochondrion • plasma membrane • integral to plasma membrane
Biological Process:	• nucleosome assembly • ion transport • sodium ion transport • fluid secretion • organic cation transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003059 (mRNA)
NP_003050 (protein)

NM_019687 (mRNA)
NP_062661 (protein)

Location

Chr 5: 131.66 - 131.71 Mb

Chr 11: 53.83 - 53.87 Mb

Pubmed search

[1]

[2]

Solute carrier family 22 (organic cation transporter), member 4, also known as SLC22A4, is a human gene.^[1]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC22A4 solute carrier family 22 (organic cation transporter), member 4.

[edit] Further reading

Xuan W, Lamhonwah AM, Librach C, et al. (2003). "Characterization of organic cation/carnitine transporter family in human sperm.". Biochem. Biophys. Res. Commun. 306 (1): 121–8. PMID 12788076.
Yamada R, Tokuhiro S, Chang X, Yamamoto K (2005). "SLC22A4 and RUNX1: identification of RA susceptible genes.". J. Mol. Med. 82 (9): 558–64. doi:10.1007/s00109-004-0547-y. PMID 15184985.
Silverberg MS (2006). "OCTNs: will the real IBD5 gene please stand up?". World J. Gastroenterol. 12 (23): 3678–81. PMID 16773684.
Tamai I, Yabuuchi H, Nezu J, et al. (1998). "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1.". FEBS Lett. 419 (1): 107–11. PMID 9426230.
Meyer-Wentrup F, Karbach U, Gorboulev V, et al. (1998). "Membrane localization of the electrogenic cation transporter rOCT1 in rat liver.". Biochem. Biophys. Res. Commun. 248 (3): 673–8. doi:10.1006/bbrc.1998.9034. PMID 9703985.
Urakami Y, Okuda M, Masuda S, et al. (1998). "Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.". J. Pharmacol. Exp. Ther. 287 (2): 800–5. PMID 9808712.
Yabuuchi H, Tamai I, Nezu J, et al. (1999). "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.". J. Pharmacol. Exp. Ther. 289 (2): 768–73. PMID 10215651.
Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction.". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627.
Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population.". J. Hum. Genet. 47 (11): 576–84. doi:10.1007/s100380200088. PMID 12436193.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Eraly SA, Hamilton BA, Nigam SK (2003). "Organic anion and cation transporters occur in pairs of similar and similarly expressed genes.". Biochem. Biophys. Res. Commun. 300 (2): 333–42. PMID 12504088.
Gisler SM, Pribanic S, Bacic D, et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Tokuhiro S, Yamada R, Chang X, et al. (2004). "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.". Nat. Genet. 35 (4): 341–8. doi:10.1038/ng1267. PMID 14608356.
Peltekova VD, Wintle RF, Rubin LA, et al. (2004). "Functional variants of OCTN cation transporter genes are associated with Crohn disease.". Nat. Genet. 36 (5): 471–5. doi:10.1038/ng1339. PMID 15107849.
Kawasaki Y, Kato Y, Sai Y, Tsuji A (2005). "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population.". Journal of pharmaceutical sciences 93 (12): 2920–6. doi:10.1002/jps.20190. PMID 15459889.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Newman B, Gu X, Wintle R, et al. (2005). "A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.". Gastroenterology 128 (2): 260–9. PMID 15685536.
Gründemann D, Harlfinger S, Golz S, et al. (2005). "Discovery of the ergothioneine transporter.". Proc. Natl. Acad. Sci. U.S.A. 102 (14): 5256–61. doi:10.1073/pnas.0408624102. PMID 15795384.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)