SLC22A3

From Wikipedia, the free encyclopedia

Solute carrier family 22 (extraneuronal monoamine transporter), member 3

Identifiers

SLC22A3; EMT; OCT3; EMTH

External IDs

OMIM: 604842 MGI: 1333817 HomoloGene: 22630

Gene ontology
Molecular Function:	• ion transmembrane transporter activity • organic cation transmembrane transporter activity
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane
Biological Process:	• ion transport • organic cation transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021977 (mRNA)
NP_068812 (protein)

XM_977528 (mRNA)
XP_982622 (protein)

Location

Chr 6: 160.69 - 160.8 Mb

Chr 17: 12.26 - 12.35 Mb

Pubmed search

[1]

[2]

Solute carrier family 22 (extraneuronal monoamine transporter), member 3, also known as SLC22A3, is a human gene.^[1]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3.

[edit] Further reading

Kekuda R, Prasad PD, Wu X, et al. (1998). "Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta.". J. Biol. Chem. 273 (26): 15971–9. PMID 9632645.
Wu X, Kekuda R, Huang W, et al. (1999). "Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain.". J. Biol. Chem. 273 (49): 32776–86. PMID 9830022.
Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.". Genomics 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
Gründemann D, Schechinger B, Rappold GA, Schömig E (1999). "Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.". Nat. Neurosci. 1 (5): 349–51. doi:10.1038/1557. PMID 10196521.
Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2.". Hum. Genet. 106 (6): 627–35. PMID 10942111.
Wu X, Huang W, Ganapathy ME, et al. (2000). "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.". Am. J. Physiol. Renal Physiol. 279 (3): F449–58. PMID 10966924.
Wieland A, Hayer-Zillgen M, Bönisch H, Brüss M (2001). "Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3) extraneuronal monoamine transporter.". Journal of neural transmission (Vienna, Austria : 1996) 107 (10): 1149–57. PMID 11129104.
Wessler I, Roth E, Deutsch C, et al. (2001). "Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.". Br. J. Pharmacol. 134 (5): 951–6. doi:10.1038/sj.bjp.0704335. PMID 11682442.
Martel F, Keating E, Calhau C, et al. (2002). "Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems.". Naunyn Schmiedebergs Arch. Pharmacol. 364 (6): 487–95. PMID 11770002.
Hayer-Zillgen M, Brüss M, Bönisch H (2003). "Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3.". Br. J. Pharmacol. 136 (6): 829–36. doi:10.1038/sj.bjp.0704785. PMID 12110607.
Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837.
Lazar A, Gründemann D, Berkels R, et al. (2003). "Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3).". J. Hum. Genet. 48 (5): 226–30. doi:10.1007/s10038-003-0015-5. PMID 12768439.
Haag C, Berkels R, Gründemann D, et al. (2004). "The localisation of the extraneuronal monoamine transporter (EMT) in rat brain.". J. Neurochem. 88 (2): 291–7. PMID 14690517.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.". Placenta 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
Jiang W, Prokopenko O, Wong L, et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMID 16024787.
Bourdet DL, Pritchard JB, Thakker DR (2006). "Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).". J. Pharmacol. Exp. Ther. 315 (3): 1288–97. doi:10.1124/jpet.105.091223. PMID 16141367.
Aoyama N, Takahashi N, Kitaichi K, et al. (2006). "Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder.". Alcohol. Clin. Exp. Res. 30 (10): 1644–9. doi:10.1111/j.1530-0277.2006.00215.x. PMID 17010131.
Bottalico B, Noskova V, Pilka R, et al. (2007). "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.". Mol. Reprod. Dev. 74 (10): 1303–11. doi:10.1002/mrd.20697. PMID 17393420.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)