SLC22A1

From Wikipedia, the free encyclopedia

Solute carrier family 22 (organic cation transporter), member 1

Identifiers

SLC22A1; OCT1; HOCT1; oct1_cds

External IDs

OMIM: 602607 MGI: 108111 HomoloGene: 20665

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • ATP binding • ion transmembrane transporter activity • organic cation transmembrane transporter activity • symporter activity • sodium ion binding
Cellular Component:	• membrane fraction • integral to plasma membrane • membrane • integral to membrane
Biological Process:	• ion transport • sodium ion transport • organic cation transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003057 (mRNA)
NP_003048 (protein)

NM_009202 (mRNA)
NP_033228 (protein)

Location

Chr 6: 160.46 - 160.5 Mb

Chr 17: 12.49 - 12.52 Mb

Pubmed search

[1]

[2]

Solute carrier family 22 (organic cation transporter), member 1, also known as SLC22A1, is a human gene.^[1]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.^[1]

[edit] See also

Solute carrier family

[edit] References

^ ^a ^b Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1.

[edit] Further reading

Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat.". J. Virol. 66 (1): 139–49. PMID 1727476.
Jeang KT, Chun R, Lin NH, et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.". J. Virol. 67 (10): 6224–33. PMID 7690421.
Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor.". AIDS 10 (12): 1323–9. PMID 8902060.
Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat.". Biochem. J. 322 ( Pt 1): 155–8. PMID 9078256.
Zhang L, Dresser MJ, Gray AT, et al. (1997). "Cloning and functional expression of a human liver organic cation transporter.". Mol. Pharmacol. 51 (6): 913–21. PMID 9187257.
Gorboulev V, Ulzheimer JC, Akhoundova A, et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters.". DNA Cell Biol. 16 (7): 871–81. PMID 9260930.
Koehler MR, Wissinger B, Gorboulev V, et al. (1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26.". Cytogenet. Cell Genet. 79 (3-4): 198–200. PMID 9605850.
Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.". Genomics 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568.
Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.". Genes Dev. 13 (20): 2650–7. PMID 10541551.
Tomilin A, Reményi A, Lins K, et al. (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.". Cell 103 (6): 853–64. PMID 11136971.
Hayer M, Bönisch H, Brüss M (2001). "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1).". Ann. Hum. Genet. 63 (Pt 6): 473–82. doi:10.1017/S0003480099007770. PMID 11388889.
Pietig G, Mehrens T, Hirsch JR, et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules.". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227.
Pan H, Qin WX, Huo KK, et al. (2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.". Genomics 77 (1-2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.
Schinkel AH, Jonker JW (2003). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics 12 (8): 589–90. PMID 12439217.
Kerb R, Brinkmann U, Chatskaia N, et al. (2003). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.". Pharmacogenetics 12 (8): 591–5. PMID 12439218.
Schaffer A, Kim EC, Wu X, et al. (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements.". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812.
Shu Y, Leabman MK, Feng B, et al. (2003). "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5902–7. doi:10.1073/pnas.0730858100. PMID 12719534.
Sakata T, Anzai N, Shin HJ, et al. (2004). "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.". Biochem. Biophys. Res. Commun. 313 (3): 789–93. PMID 14697261.
Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.". Placenta 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)