SLC16A2

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Solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
Identifiers
Symbol(s) SLC16A2; AHDS; DXS128; DXS128E; MCT7; MCT8; XPCT
External IDs OMIM: 300095 MGI: 1203732 HomoloGene: 39495
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6567 20502
Ensembl ENSG00000147100 ENSMUSG00000033965
Uniprot P36021 Q05BA2
Refseq NM_006517 (mRNA)
NP_006508 (protein)		 NM_009197 (mRNA)
NP_033223 (protein)
Location Chr X: 73.56 - 73.67 Mb Chr X: 99.9 - 100.02 Mb
Pubmed search [1] [2]

Solute carrier family 16, member 2 (monocarboxylic acid transporter 8), also known as SLC16A2, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: SLC16A2 solute carrier family 16, member 2 (monocarboxylic acid transporter 8).

[edit] Further reading

  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. 
  • Friesema EC, Jansen J, Heuer H, et al. (2006). "Mechanisms of disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8.". Nature clinical practice. Endocrinology & metabolism 2 (9): 512–23. doi:10.1038/ncpendmet0262. PMID 16957765. 
  • Grüters A (2007). "Thyroid hormone transporter defects.". Endocrine development 10: 118–26. doi:10.1159/0000106823. PMID 17684393. 
  • Lafrenière RG, Carrel L, Willard HF (1995). "A novel transmembrane transporter encoded by the XPCT gene in Xq13.2.". Hum. Mol. Genet. 3 (7): 1133–9. PMID 7981683. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Price NT, Jackson VN, Halestrap AP (1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.". Biochem. J. 329 ( Pt 2): 321–8. PMID 9425115. 
  • Debrand E, Heard E, Avner P (1998). "Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene.". Genomics 48 (3): 296–303. doi:10.1006/geno.1997.5173. PMID 9545634. 
  • Friesema EC, Ganguly S, Abdalla A, et al. (2003). "Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter.". J. Biol. Chem. 278 (41): 40128–35. doi:10.1074/jbc.M300909200. PMID 12871948. 
  • Dumitrescu AM, Liao XH, Best TB, et al. (2004). "A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.". Am. J. Hum. Genet. 74 (1): 168–75. PMID 14661163. 
  • Friesema EC, Grueters A, Biebermann H, et al. (2004). "Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation.". Lancet 364 (9443): 1435–7. doi:10.1016/S0140-6736(04)17226-7. PMID 15488219. 
  • Heuer H, Maier MK, Iden S, et al. (2005). "The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations.". Endocrinology 146 (4): 1701–6. doi:10.1210/en.2004-1179. PMID 15661862. 
  • Brockmann K, Dumitrescu AM, Best TT, et al. (2005). "X-linked paroxysmal dyskinesia and severe global retardation caused by defective MCT8 gene.". J. Neurol. 252 (6): 663–6. doi:10.1007/s00415-005-0713-3. PMID 15834651. 
  • Schwartz CE, May MM, Carpenter NJ, et al. (2005). "Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene.". Am. J. Hum. Genet. 77 (1): 41–53. doi:10.1086/431313. PMID 15889350. 
  • Friesema EC, Kuiper GG, Jansen J, et al. (2007). "Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism.". Mol. Endocrinol. 20 (11): 2761–72. doi:10.1210/me.2005-0256. PMID 16887882. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Jansen J, Friesema EC, Kester MH, et al. (2007). "Functional analysis of monocarboxylate transporter 8 mutations identified in patients with X-linked psychomotor retardation and elevated serum triiodothyronine.". J. Clin. Endocrinol. Metab. 92 (6): 2378–81. doi:10.1210/jc.2006-2570. PMID 17356046. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other