SLC16A1

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Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Identifiers
Symbol(s) SLC16A1; MCT1; FLJ36745; MCT; MGC44475
External IDs OMIM: 600682 MGI: 106013 HomoloGene: 20662
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6566 20501
Ensembl ENSG00000155380 ENSMUSG00000032902
Uniprot P53985 Q3TIU1
Refseq NM_003051 (mRNA)
NP_003042 (protein)		 NM_009196 (mRNA)
NP_033222 (protein)
Location Chr 1: 113.26 - 113.3 Mb Chr 3: 104.77 - 104.79 Mb
Pubmed search [1] [2]

Solute carrier family 16, member 1 (monocarboxylic acid transporter 1), also known as SLC16A1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1).

[edit] Further reading

  • Bonen A (2002). "The expression of lactate transporters (MCT1 and MCT4) in heart and muscle.". Eur. J. Appl. Physiol. 86 (1): 6-11. PMID 11820324. 
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619-28. doi:10.1007/s00424-003-1067-2. PMID 12739169. 
  • Kim CM, Goldstein JL, Brown MS (1992). "cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.". J. Biol. Chem. 267 (32): 23113-21. PMID 1429658. 
  • Garcia CK, Li X, Luna J, Francke U (1995). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12.". Genomics 23 (2): 500-3. doi:10.1006/geno.1994.1532. PMID 7835905. 
  • Garcia CK, Goldstein JL, Pathak RK, et al. (1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle.". Cell 76 (5): 865-73. PMID 8124722. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Ritzhaupt A, Wood IS, Ellis A, et al. (1999). "Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate.". J. Physiol. (Lond.) 513 ( Pt 3): 719-32. PMID 9824713. 
  • Rahman B, Schneider HP, Bröer A, et al. (1999). "Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1.". Biochemistry 38 (35): 11577-84. doi:10.1021/bi990973f. PMID 10471310. 
  • Brooks GA, Brown MA, Butz CE, et al. (1999). "Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.". J. Appl. Physiol. 87 (5): 1713-8. PMID 10562613. 
  • Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW (2000). "Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport.". Muscle Nerve 23 (1): 90-7. PMID 10590411. 
  • Kirk P, Wilson MC, Heddle C, et al. (2000). "CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.". EMBO J. 19 (15): 3896-904. doi:10.1093/emboj/19.15.3896. PMID 10921872. 
  • Cuff MA, Lambert DW, Shirazi-Beechey SP (2002). "Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1.". J. Physiol. (Lond.) 539 (Pt 2): 361-71. PMID 11882670. 
  • Cuff MA, Shirazi-Beechey SP (2002). "The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis.". Biochem. Biophys. Res. Commun. 292 (4): 1048-56. doi:10.1006/bbrc.2002.6763. PMID 11944921. 
  • Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP (2002). "Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy.". Br. J. Cancer 86 (8): 1262-9. doi:10.1038/sj.bjc.6600264. PMID 11953883. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Zhang GZ, Huang GJ, Li WL, et al. (2002). "[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells]". Ai Zheng 21 (7): 719-23. PMID 12479094. 
  • Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716-21. PMID 12657613. 
  • Asada K, Miyamoto K, Fukutomi T, et al. (2003). "Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.". Oncology 64 (4): 380-8. doi:10.1159/000070297. PMID 12759536. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other