SLC10A2

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Solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Identifiers
Symbol(s) SLC10A2; ASBT; ISBT; NTCP2
External IDs OMIM: 601295 MGI: 1201406 HomoloGene: 390
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6555 20494
Ensembl ENSG00000125255 ENSMUSG00000023073
Uniprot Q12908 Q0VBB8
Refseq NM_000452 (mRNA)
NP_000443 (protein)		 NM_011388 (mRNA)
NP_035518 (protein)
Location Chr 13: 102.49 - 102.52 Mb Chr 8: 5.09 - 5.11 Mb
Pubmed search [1] [2]

Solute carrier family 10 (sodium/bile acid cotransporter family), member 2, also known as SLC10A2, is a human gene.[1]


[edit] See also

[edit] References

  1. ^ Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2.

[edit] Further reading

  • Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology.". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407-17. PMID 11396803. 
  • Balakrishnan A, Polli JE (2006). "Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target.". Mol. Pharm. 3 (3): 223-30. doi:10.1021/mp060022d. PMID 16749855. 
  • Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.". J. Biol. Chem. 270 (45): 27228-34. PMID 7592981. 
  • Wong MH, Rao PN, Pettenati MJ, Dawson PA (1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33.". Genomics 33 (3): 538-40. doi:10.1006/geno.1996.0233. PMID 8661017. 
  • Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).". J. Clin. Invest. 99 (8): 1880-7. PMID 9109432. 
  • Craddock AL, Love MW, Daniel RW, et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.". Am. J. Physiol. 274 (1 Pt 1): G157-69. PMID 9458785. 
  • Montagnani M, Love MW, Rössel P, et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption.". Scand. J. Gastroenterol. 36 (10): 1077-80. PMID 11589382. 
  • Love MW, Craddock AL, Angelin B, et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia.". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039-45. PMID 11742882. 
  • Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha.". J. Biol. Chem. 277 (34): 30559-66. doi:10.1074/jbc.M203511200. PMID 12055195. 
  • Zelcer N, Saeki T, Bot I, et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter.". Biochem. J. 369 (Pt 1): 23-30. doi:10.1042/BJ20021081. PMID 12220224. 
  • Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675-80. doi:10.1073/pnas.182412499. PMID 12364586. 
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522-8. doi:10.1038/nature02379. PMID 15057823. 
  • Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.". Hepatology 40 (1): 149-56. doi:10.1002/hep.20295. PMID 15239098. 
  • Xia X, Roundtree M, Merikhi A, et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.". J. Biol. Chem. 279 (43): 44931-7. doi:10.1074/jbc.M400969200. PMID 15304498. 
  • Zhang EY, Phelps MA, Banerjee A, et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 43 (36): 11380-92. doi:10.1021/bi049270a. PMID 15350125. 
  • Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 44 (24): 8908-17. doi:10.1021/bi050553s. PMID 15952798. 
  • Nakahara M, Furuya N, Takagaki K, et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.". J. Biol. Chem. 280 (51): 42283-9. doi:10.1074/jbc.M507454200. PMID 16230354. 
  • Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.". J. Lipid Res. 47 (1): 42-50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211. 
  • Banerjee A, Swaan PW (2006). "Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains.". Biochemistry 45 (3): 943-53. doi:10.1021/bi052202j. PMID 16411770. 
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v • d • e
Membrane proteins, carrier proteins: membrane transport proteins
ABC-transporter
A1, A2, A3, A4, A7, A8, A12, B1

B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
Other