SLAMF8

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SLAM family member 8
Identifiers
Symbol(s) SLAMF8; FLJ20442; BLAME; MGC129578; SBBI42
External IDs OMIM: 606620 MGI: 1921998 HomoloGene: 10589
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 56833 74748
Ensembl ENSG00000158714 ENSMUSG00000053318
Uniprot Q9P0V8 Q18PH1
Refseq NM_020125 (mRNA)
NP_064510 (protein)		 XM_993718 (mRNA)
XP_998812 (protein)
Location Chr 1: 158.06 - 158.07 Mb Chr 1: 174.42 - 174.43 Mb
Pubmed search [1] [2]

SLAM family member 8, also known as SLAMF8, is a human gene.[1]

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.[1]

[edit] References

  1. ^ a b Entrez Gene: SLAMF8 SLAM family member 8.

[edit] Further reading

  • Kingsbury GA, Feeney LA, Nong Y, et al. (2001). "Cloning, expression, and function of BLAME, a novel member of the CD2 family.". J. Immunol. 166 (9): 5675–80. PMID 11313408. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.". J. Immunol. 171 (5): 2485–95. PMID 12928397. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
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