SLAMF6

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SLAM family member 6
PDB rendering based on 2if7.
Available structures: 2if7
Identifiers
Symbol(s) SLAMF6; KALI; KALIb; Ly108; MGC104953; NTB-A; NTBA; SF2000
External IDs OMIM: 606446 MGI: 1353620 HomoloGene: 49945
Orthologs
Human Mouse
Entrez 114836 30925
Ensembl ENSG00000162739 ENSMUSG00000015314
Uniprot Q96DU3 Q18PJ0
Refseq NM_052931 (mRNA)
NP_443163 (protein)		 NM_030710 (mRNA)
NP_109635 (protein)
Location Chr 1: 158.72 - 158.76 Mb Chr 1: 173.75 - 173.79 Mb
Pubmed search [1] [2]

SLAM family member 6, also known as SLAMF6, is a human gene.[1]

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.[1]

[edit] References

  1. ^ a b Entrez Gene: SLAMF6 SLAM family member 6.

[edit] Further reading

  • Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC.". Front. Biosci. 13: 956-65. PMID 17981603. 
  • Hercend T, Meuer S, Brennan A, et al. (1984). "Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure.". Cell. Immunol. 86 (2): 381-92. PMID 6610481. 
  • Kong G, Dalton M, Wardenburg JB, et al. (1996). "Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function.". Mol. Cell. Biol. 16 (9): 5026-35. PMID 8756661. 
  • Lee YJ, Luisiri P, Clark MR (1996). "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation.". J. Immunol. 157 (9): 3828-37. PMID 8892612. 
  • Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.". Eur. J. Biochem. 267 (18): 5699-710. PMID 10971580. 
  • Bottino C, Falco M, Parolini S, et al. (2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease.". J. Exp. Med. 194 (3): 235-46. PMID 11489943. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430-7. doi:10.1074/jbc.M301569200. PMID 12621057. 
  • Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.". J. Immunol. 171 (5): 2485-95. PMID 12928397. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Valdez PA, Wang H, Seshasayee D, et al. (2004). "NTB-A, a new activating receptor in T cells that regulates autoimmune disease.". J. Biol. Chem. 279 (18): 18662-9. doi:10.1074/jbc.M312313200. PMID 14988414. 
  • Flaig RM, Stark S, Watzl C (2004). "Cutting edge: NTB-A activates NK cells via homophilic interaction.". J. Immunol. 172 (11): 6524-7. PMID 15153464. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Stark S, Watzl C (2006). "2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells.". Int. Immunol. 18 (2): 241-7. doi:10.1093/intimm/dxh358. PMID 16410313. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414. 
  • Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.". J. Immunol. 177 (5): 3170-7. PMID 16920955. 
  • Cao E, Ramagopal UA, Fedorov A, et al. (2006). "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family.". Immunity 25 (4): 559-70. doi:10.1016/j.immuni.2006.06.020. PMID 17045824. 
  • Banerjee P, Feuer G, Barker E (2007). "Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells.". J. Virol. 81 (18): 9707-17. doi:10.1128/JVI.00887-07. PMID 17609265. 
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