SLA2

From Wikipedia, the free encyclopedia

Src-like-adaptor 2

Identifiers

SLA2; C20orf156; FLJ21992; MGC49845; SLAP-2; SLAP2

External IDs

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • protein N-terminus binding
Cellular Component:	• cytoplasm • late endosome • plasma membrane • endosome membrane • cytoplasmic membrane-bound vesicle
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • B cell mediated immunity • intracellular receptor-mediated signaling pathway • T cell activation • regulation of immune response • negative regulation of calcium-mediated signaling • antigen receptor-mediated signaling pathway • negative regulation of B cell activation

Orthologs

Human

Mouse

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Refseq

NM_032214 (mRNA)
NP_115590 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 20: 34.67 - 34.71 Mb

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Pubmed search

[1]

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Src-like-adaptor 2, also known as SLA2, is a human gene.^[1]

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SLA2 Src-like-adaptor 2.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v.". Oncogene 22 (2): 266-73. doi:10.1038/sj.onc.1206114. PMID 12527895.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.". Mol. Cell. Biol. 22 (12): 4241-55. PMID 12024036.
Pandey A, Ibarrola N, Kratchmarova I, et al. (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.". J. Biol. Chem. 277 (21): 19131-8. doi:10.1074/jbc.M110318200. PMID 11891219.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Holland SJ, Liao XC, Mendenhall MK, et al. (2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling.". J. Exp. Med. 194 (9): 1263-76. PMID 11696592.