SKIV2L

From Wikipedia, the free encyclopedia

Superkiller viralicidic activity 2-like (S. cerevisiae)

Identifiers

SKIV2L; HLP; 170A; DDX13; SKI2; SKI2W; SKIV2

External IDs

OMIM: 600478 MGI: 1099835 HomoloGene: 6532

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • ATP-dependent RNA helicase activity • protein binding • ATP binding • ATP-dependent helicase activity • hydrolase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006929 (mRNA)
NP_008860 (protein)

NM_021337 (mRNA)
NP_067312 (protein)

Location

Chr 6: 32.03 - 32.05 Mb

Chr 17: 34.45 - 34.46 Mb

Pubmed search

[1]

[2]

Superkiller viralicidic activity 2-like (S. cerevisiae), also known as SKIV2L, is a human gene.^[1]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex.^[1]

[edit] References

^ ^a ^b Entrez Gene: SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae).

[edit] Further reading

Yang Z, Qu X, Yu CY (2001). "Features of the two gene pairs RD-SKI2W and DOM3Z-RP1 located between complement component genes factor B and C4 at the MHC class III region.". Front. Biosci. 6: D927–35. PMID 11487501.
Dangel AW, Shen L, Mendoza AR, et al. (1995). "Human helicase gene SKI2W in the HLA class III region exhibits striking structural similarities to the yeast antiviral gene SKI2 and to the human gene KIAA0052: emergence of a new gene family.". Nucleic Acids Res. 23 (12): 2120–6. PMID 7610041.
Lee SG, Lee I, Park SH, et al. (1995). "Identification and characterization of a human cDNA homologous to yeast SKI2.". Genomics 25 (3): 660–6. PMID 7759100.
Shen L, Wu LC, Sanlioglu S, et al. (1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.". J. Biol. Chem. 269 (11): 8466–76. PMID 8132574.
Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).". Genomics 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
Lee SG, Song K (1997). "Genomic organization of the human DDX13 gene located between RD and RP1 in the class III MHC complex.". Mol. Cells 7 (3): 414–8. PMID 9264031.
Qu X, Yang Z, Zhang S, et al. (1998). "The human DEVH-box protein Ski2w from the HLA is localized in nucleoli and ribosomes.". Nucleic Acids Res. 26 (17): 4068–77. PMID 9705521.
Yang Z, Shen L, Dangel AW, et al. (1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA.". Genomics 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
Lee SG, Song K (2000). "Identification and characterization of a bidirectional promoter from the intergenic region between the human DDX13 and RD genes.". Mol. Cells 10 (1): 47–53. PMID 10774746.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.". Cell 107 (4): 451–64. PMID 11719186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Yang CT, Hindes AE, Hultman KA, Johnson SL (2007). "Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish.". PLoS Genet. 3 (6): e88. doi:10.1371/journal.pgen.0030088. PMID 17542649.