SKIL

From Wikipedia, the free encyclopedia

SKI-like oncogene

Identifiers

SKIL; SNO; SnoA; SnoN

External IDs

OMIM: 165340 MGI: 106203 HomoloGene: 3948

Gene ontology
Molecular Function:	• DNA binding • transcription corepressor activity • transforming growth factor beta receptor, cytoplasmic mediator activity • protein binding
Cellular Component:	• nucleus
Biological Process:	• transcription from RNA polymerase II promoter • signal transduction • multicellular organismal development • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005414 (mRNA)
NP_005405 (protein)

NM_001039090 (mRNA)
NP_001034179 (protein)

Location

Chr 3: 171.56 - 171.59 Mb

Chr 3: 31.29 - 31.31 Mb

Pubmed search

[1]

[2]

SKI-like oncogene, also known as SKIL, is a human gene.^[1]

[edit] References

^ Entrez Gene: SKIL SKI-like oncogene.

[edit] Further reading

Nomura N, Sasamoto S, Ishii S, et al. (1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno.". Nucleic Acids Res. 17 (14): 5489–500. PMID 2762147.
Pearson-White S (1993). "SnoI, a novel alternatively spliced isoform of the ski protooncogene homolog, sno.". Nucleic Acids Res. 21 (19): 4632–8. PMID 8233802.
Pearson-White S, Crittenden R (1997). "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response.". Nucleic Acids Res. 25 (14): 2930–7. PMID 9207045.
Cohen SB, Zheng G, Heyman HC, Stavnezer E (1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents.". Nucleic Acids Res. 27 (4): 1006–14. PMID 9927733.
Stroschein SL, Wang W, Zhou S, et al. (1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein.". Science 286 (5440): 771–4. PMID 10531062.
Bonni S, Wang HR, Causing CG, et al. (2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.". Nat. Cell Biol. 3 (6): 587–95. doi:10.1038/35078562. PMID 11389444.
Imoto I, Pimkhaokham A, Fukuda Y, et al. (2001). "SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus.". Biochem. Biophys. Res. Commun. 286 (3): 559–65. doi:10.1006/bbrc.2001.5428. PMID 11511096.
Stroschein SL, Bonni S, Wrana JL, Luo K (2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.". Genes Dev. 15 (21): 2822–36. doi:10.1101/gad.912901. PMID 11691834.
Mizuide M, Hara T, Furuya T, et al. (2003). "Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN.". J. Biol. Chem. 278 (1): 531–6. doi:10.1074/jbc.C200596200. PMID 12426322.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
He J, Tegen SB, Krawitz AR, et al. (2003). "The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins.". J. Biol. Chem. 278 (33): 30540–7. doi:10.1074/jbc.M304016200. PMID 12764135.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sarker KP, Wilson SM, Bonni S (2005). "SnoN is a cell type-specific mediator of transforming growth factor-beta responses.". J. Biol. Chem. 280 (13): 13037–46. doi:10.1074/jbc.M409367200. PMID 15677458.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Poser I, Rothhammer T, Dooley S, et al. (2005). "Characterization of Sno expression in malignant melanoma.". Int. J. Oncol. 26 (5): 1411–7. PMID 15809735.
Krakowski AR, Laboureau J, Mauviel A, et al. (2005). "Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins.". Proc. Natl. Acad. Sci. U.S.A. 102 (35): 12437–42. doi:10.1073/pnas.0504107102. PMID 16109768.
Zhu Q, Pearson-White S, Luo K (2006). "Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.". Mol. Cell. Biol. 25 (24): 10731–44. doi:10.1128/MCB.25.24.10731-10744.2005. PMID 16314499.
Briones-Orta MA, Sosa-Garrocho M, Moreno-Alvarez P, et al. (2006). "SnoN co-repressor binds and represses smad7 gene promoter.". Biochem. Biophys. Res. Commun. 341 (3): 889–94. doi:10.1016/j.bbrc.2006.01.041. PMID 16442497.