SIX5

From Wikipedia, the free encyclopedia

Sine oculis homeobox homolog 5 (Drosophila)

Identifiers

SIX5; DMAHP

External IDs

OMIM: 600963 MGI: 106220 HomoloGene: 72248

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_175875 (mRNA)
NP_787071 (protein)

NM_011383 (mRNA)
NP_035513 (protein)

Location

Chr 19: 50.96 - 50.96 Mb

Chr 7: 18.25 - 18.26 Mb

Pubmed search

[1]

[2]

Sine oculis homeobox homolog 5 (Drosophila), also known as SIX5, is a human gene.^[1]

[edit] References

^ Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila).

[edit] Further reading

Boucher CA, King SK, Carey N, et al. (1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat.". Hum. Mol. Genet. 4 (10): 1919-25. PMID 8595416.
Murakami Y, Ohto H, Ikeda U, et al. (1999). "Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements.". Hum. Mol. Genet. 7 (13): 2103-12. PMID 9817928.
Winchester CL, Ferrier RK, Sermoni A, et al. (1999). "Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy.". Hum. Mol. Genet. 8 (3): 481-92. PMID 9949207.
Ohto H, Kamada S, Tago K, et al. (2000). "Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.". Mol. Cell. Biol. 19 (10): 6815-24. PMID 10490620.
Harris SE, Winchester CL, Johnson KJ (2000). "Functional analysis of the homeodomain protein SIX5.". Nucleic Acids Res. 28 (9): 1871-8. PMID 10756185.
Winchester C, Robertson S, MacLeod T, et al. (2000). "Expression of a homeobox gene (SIX5) in borderline ovarian tumours.". J. Clin. Pathol. 53 (3): 212-7. PMID 10823141.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021-8. doi:10.1074/jbc.M108417200. PMID 11748221.
Sato S, Nakamura M, Cho DH, et al. (2002). "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1.". Hum. Mol. Genet. 11 (9): 1045-58. PMID 11978764.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fougerousse F, Durand M, Lopez S, et al. (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation.". J. Muscle Res. Cell. Motil. 23 (3): 255-64. PMID 12500905.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Hoskins BE, Cramer CH, Silvius D, et al. (2007). "Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome.". Am. J. Hum. Genet. 80 (4): 800-4. doi:10.1086/513322. PMID 17357085.