SIX4

From Wikipedia, the free encyclopedia

Sine oculis homeobox homolog 4 (Drosophila)

Identifiers

SIX4; AREC3; MGC119450; MGC119452; MGC119453

External IDs

OMIM: 606342 MGI: 106034 HomoloGene: 69089

Gene ontology
Molecular Function:	• transcription factor activity • sequence-specific DNA binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • striated muscle development • inner ear morphogenesis • positive regulation of transcription • embryonic skeletal morphogenesis • myoblast migration

Orthologs

Human

Mouse

Refseq

NM_017420 (mRNA)
NP_059116 (protein)

XM_001001466 (mRNA)
XP_001001466 (protein)

Location

Chr 14: 60.25 - 60.26 Mb

Chr 12: 74.02 - 74.03 Mb

Pubmed search

[1]

[2]

Sine oculis homeobox homolog 4 (Drosophila), also known as SIX4, is a human gene.^[1]

[edit] References

^ Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila).

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family.". Development 130 (1): 185-95. PMID 12441302.
Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.". Mol. Cell. Biol. 22 (19): 6759-66. PMID 12215533.
Fan X, Brass LF, Poncz M, et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins.". J. Biol. Chem. 275 (41): 32129-34. doi:10.1074/jbc.M004577200. PMID 10906137.
Ozaki H, Yamada K, Kobayashi M, et al. (2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes.". Cytogenet. Cell Genet. 87 (1-2): 108-12. PMID 10640827.
Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, et al. (1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies.". Genomics 61 (1): 82-91. doi:10.1006/geno.1999.5916. PMID 10512683.
Kawakami K, Ohto H, Ikeda K, Roeder RG (1996). "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development.". Nucleic Acids Res. 24 (2): 303-10. PMID 8628654.