SIT1

From Wikipedia, the free encyclopedia

Signaling threshold regulating transmembrane adaptor 1

Identifiers

SIT1; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SIT

External IDs

OMIM: 604964 MGI: 1889342 HomoloGene: 8694

Gene ontology
Molecular Function:	• protein binding • kinase binding • SH2 domain binding
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• immune response • signal transduction • regulation of T cell activation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014450 (mRNA)
NP_055265 (protein)

NM_019436 (mRNA)
NP_062309 (protein)

Location

Chr 9: 35.64 - 35.64 Mb

Chr 4: 43.5 - 43.5 Mb

Pubmed search

[1]

[2]

Signaling threshold regulating transmembrane adaptor 1, also known as SIT1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1.

[edit] Further reading

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Marie-Cardine A, Kirchgessner H, Bruyns E, et al. (1999). "SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.". J. Exp. Med. 189 (8): 1181–94. PMID 10209036.
Pfrepper KI, Marie-Cardine A, Simeoni L, et al. (2001). "Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).". Eur. J. Immunol. 31 (6): 1825–36. PMID 11433379.
Hübener C, Mincheva A, Lichter P, et al. (2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT).". Immunogenetics 53 (4): 337–41. PMID 11491537.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites.". Rapid Commun. Mass Spectrom. 19 (1): 57–71. doi:10.1002/rcm.1746. PMID 15570572.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers.". Blood 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.