Talk:Silibinin

From Wikipedia, the free encyclopedia

	Silibinin is part of WikiProject Pharmacology, a project to improve all Pharmacology-related articles. If you would like to help improve this and other pharmacology articles, please join the project. All interested editors are welcome.
Start	This article has been rated as Start-Class on the quality scale.
Mid	This article has been rated as Mid-importance for this Project's importance scale.

[edit] disintegration of the tissue

unable to vetify this information!!! I introduced some more info on the toxicity (very very low) of the compound

[edit] treatment of what?

The last para of this article states: "Silymarin is among the popular complementary medicine for the treatment. "

This doesn't make sense to me - could someone rephrase? Smalljim 13:19, 7 February 2007 (UTC)

[edit] a few citations

A few comments, additions and citations to this entry. First, there is an entire journal issue devoted to the uses of silymarin in cancer (breast, skin, prostate, etc). See Integrative Cancer Therapies 6(2) 2007. For example: Deep G & Agarwal R. Chemopreventive Efficacy of Silymarin in Skin and Prostate Cancer. Pgs 130-145 of that journal will give you the citation you need for skin/prostate cancer.

Also, several articles on the use of SIL in diabetes and the prevention of diabetic neuropathy (when the retina and peripheral nerves are destroyed): Gorio A, et al. Alterations of protein mono-ADP-ribosylation and diabetic neuropathy: a novel pharmacological approach. Eur J Pharmacol 1996; 311: 21-28 McCarty M. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Med Hypotheses 2005; 64: 628-35. Velussi M, et al. Long term (12 mos) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. Jour Hepatol 1997; 26: 871-79.

Lastly, since the recommended dose for Amanita toxicosis in dogs is 50 - 150mg/kg, I doubt that the LD₅₀ in dogs is 140 mg/kg. I would be very interested in seeing the citation for those tox numbers, since I have not found any such toxicities in my research. Since my thesis is on the uses of SIL in pets, such info would be very useful. The citation for that dosage, btw is: Filburn CR, et al. Safety and bioavailability in beagles of zinc and vitamin E combined with silybin and phosphatidylcholine. Intern J Appl Res Vet Med 2006; 4(4): 326 - 34.

Thanks. Gypsyvet 10:39, 27 August 2007 (UTC)