SIGLEC9

From Wikipedia, the free encyclopedia

Sialic acid binding Ig-like lectin 9

Identifiers

SIGLEC9; CDw329; OBBP-LIKE

External IDs

Gene ontology
Molecular Function:	• protein binding • sugar binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cell adhesion • cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_014441 (mRNA)
NP_055256 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 19: 56.32 - 56.33 Mb

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Pubmed search

[1]

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Sialic acid binding Ig-like lectin 9, also known as SIGLEC9, is a human gene.^[1]

[edit] References

^ Entrez Gene: SIGLEC9 sialic acid binding Ig-like lectin 9.

[edit] Further reading

Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4.". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.
Angata T, Varki A (2000). "Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways.". J. Biol. Chem. 275 (29): 22127–35. doi:10.1074/jbc.M002775200. PMID 10801860.
Zhang JQ, Nicoll G, Jones C, Crocker PR (2000). "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.". J. Biol. Chem. 275 (29): 22121–6. doi:10.1074/jbc.M002788200. PMID 10801862.
Foussias G, Yousef GM, Diamandis EP (2000). "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9).". Genomics 67 (2): 171–8. doi:10.1006/geno.2000.6208. PMID 10903842.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Sonnenburg JL, Altheide TK, Varki A (2004). "A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor.". Glycobiology 14 (4): 339–46. doi:10.1093/glycob/cwh039. PMID 14693915.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.". J. Biol. Chem. 279 (41): 43117–25. doi:10.1074/jbc.M403538200. PMID 15292262.
Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.". J. Immunol. 173 (11): 6841–9. PMID 15557178.
von Gunten S, Yousefi S, Seitz M, et al. (2005). "Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.". Blood 106 (4): 1423–31. doi:10.1182/blood-2004-10-4112. PMID 15827126.
Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides.". Biochemistry Mosc. 71 (5): 496–504. PMID 16732727.
Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.". Leuk. Res. 31 (2): 211–20. doi:10.1016/j.leukres.2006.05.026. PMID 16828866.