SIGLEC8

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Sialic acid binding Ig-like lectin 8
Identifiers
Symbol(s) SIGLEC8; MGC59785; SAF2; SIGLEC-8; SIGLEC8L
External IDs OMIM: 605639 HomoloGene: 87865
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 27181 n/a
Ensembl ENSG00000105366 n/a
Uniprot Q9NYZ4 n/a
Refseq NM_014442 (mRNA)
NP_055257 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 19: 56.65 - 56.65 Mb n/a
Pubmed search [1] n/a

Sialic acid binding Ig-like lectin 8, also known as SIGLEC8, is a human gene.[1] SIGLEC8 has also been designated as CD329 (cluster of differentiation 329).


[edit] References

  1. ^ Entrez Gene: SIGLEC8 sialic acid binding Ig-like lectin 8.

[edit] Further reading

  • Floyd H, Ni J, Cornish AL, et al. (2000). "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily.". J. Biol. Chem. 275 (2): 861-6. PMID 10625619. 
  • Kikly KK, Bochner BS, Freeman SD, et al. (2000). "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1093-100. PMID 10856141. 
  • Foussias G, Yousef GM, Diamandis EP (2001). "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene.". Biochem. Biophys. Res. Commun. 278 (3): 775-81. doi:10.1006/bbrc.2000.3866. PMID 11095983. 
  • Munday J, Kerr S, Ni J, et al. (2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.". Biochem. J. 355 (Pt 2): 489-97. PMID 11284738. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nutku E, Aizawa H, Hudson SA, Bochner BS (2004). "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis.". Blood 101 (12): 5014-20. doi:10.1182/blood-2002-10-3058. PMID 12609831. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Bochner BS, Alvarez RA, Mehta P, et al. (2005). "Glycan array screening reveals a candidate ligand for Siglec-8.". J. Biol. Chem. 280 (6): 4307-12. doi:10.1074/jbc.M412378200. PMID 15563466. 
  • Nutku E, Hudson SA, Bochner BS (2005). "Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury.". Biochem. Biophys. Res. Commun. 336 (3): 918-24. doi:10.1016/j.bbrc.2005.08.202. PMID 16157303. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 

[edit] External links

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350