SIGLEC7
From Wikipedia, the free encyclopedia
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Sialic acid binding Ig-like lectin 7
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| PDB rendering based on 1nko. | ||||||||||||||
| Available structures: 1nko, 1o7s, 1o7v, 2df3, 2g5r, 2hrl | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | SIGLEC7; p75; AIRM1; CDw328; D-siglec; QA79; SIGLEC-7; p75/AIRM1 | |||||||||||||
| External IDs | OMIM: 604410 MGI: 1932475 HomoloGene: 88828 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 27036 | 83382 | ||||||||||||
| Ensembl | ENSG00000168995 | ENSMUSG00000030474 | ||||||||||||
| Uniprot | Q9Y286 | Q6PJ50 | ||||||||||||
| Refseq | NM_014385 (mRNA) NP_055200 (protein) |
NM_031181 (mRNA) NP_112458 (protein) |
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| Location | Chr 19: 56.34 - 56.35 Mb | Chr 7: 43.52 - 43.53 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Sialic acid binding Ig-like lectin 7, also known as SIGLEC7, is a human gene.[1] SIGLEC7 has also been designated as CD328 (cluster of differentiation 328).
[edit] References
[edit] Further reading
- Reif K, Buday L, Downward J, Cantrell DA (1994). "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.". J. Biol. Chem. 269 (19): 14081–7. PMID 8188688.
- Falco M, Biassoni R, Bottino C, et al. (1999). "Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.". J. Exp. Med. 190 (6): 793–802. PMID 10499918.
- Ye X, Mehlen P, Rabizadeh S, et al. (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.". J. Biol. Chem. 274 (42): 30202–8. PMID 10514511.
- Nicoll G, Ni J, Liu D, et al. (1999). "Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.". J. Biol. Chem. 274 (48): 34089–95. PMID 10567377.
- Vitale C, Romagnani C, Falco M, et al. (2000). "Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.". Proc. Natl. Acad. Sci. U.S.A. 96 (26): 15091–6. PMID 10611343.
- Angata T, Varki A (2000). "Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.". Glycobiology 10 (4): 431–8. PMID 10764831.
- Ito A, Handa K, Withers DA, et al. (2001). "Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression.". FEBS Lett. 498 (1): 116–20. PMID 11389909.
- Mingari MC, Vitale C, Romagnani C, et al. (2002). "Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors.". Adv. Exp. Med. Biol. 495: 55–61. PMID 11774609.
- Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.". Gene 286 (2): 259–70. PMID 11943481.
- Alphey MS, Attrill H, Crocker PR, van Aalten DM (2003). "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family.". J. Biol. Chem. 278 (5): 3372–7. doi:. PMID 12438315.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Nicoll G, Avril T, Lock K, et al. (2003). "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.". Eur. J. Immunol. 33 (6): 1642–8. doi:. PMID 12778482.
- Dimasi N, Moretta A, Moretta L, et al. (2004). "Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1.". Acta Crystallogr. D Biol. Crystallogr. 60 (Pt 2): 401–3. doi:. PMID 14747738.
- Ikehara Y, Ikehara SK, Paulson JC (2004). "Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9.". J. Biol. Chem. 279 (41): 43117–25. doi:. PMID 15292262.
- Avril T, Floyd H, Lopez F, et al. (2005). "The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells.". J. Immunol. 173 (11): 6841–9. PMID 15557178.
- Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y (2005). "Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs.". Glycobiology 15 (7): 667–76. doi:. PMID 15703304.
- Attrill H, Takazawa H, Witt S, et al. (2006). "The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.". Biochem. J. 397 (2): 271–8. doi:. PMID 16623661.
- Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides.". Biochemistry Mosc. 71 (5): 496–504. PMID 16732727.
- Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.". Leuk. Res. 31 (2): 211–20. doi:. PMID 16828866.
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