SIGLEC10

From Wikipedia, the free encyclopedia

Sialic acid binding Ig-like lectin 10

Identifiers

SIGLEC10; MGC126774; PRO940; SIGLEC-10; SLG2

External IDs

OMIM: 606091 MGI: 2443630 HomoloGene: 13228

Gene ontology
Molecular Function:	• protein binding • sugar binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• cell adhesion

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_033130 (mRNA)
NP_149121 (protein)

NM_172900 (mRNA)
NP_766488 (protein)

Location

Chr 19: 56.61 - 56.61 Mb

n/a

Pubmed search

[1]

[2]

Sialic acid binding Ig-like lectin 10, also known as SIGLEC10, is a human gene.^[1]

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10.

[edit] Further reading

Munday J, Kerr S, Ni J, et al. (2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor.". Biochem. J. 355 (Pt 2): 489–97. PMID 11284738.
Li N, Zhang W, Wan T, et al. (2001). "Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells.". J. Biol. Chem. 276 (30): 28106–12. doi:10.1074/jbc.M100467200. PMID 11358961.
Yousef GM, Ordon MH, Foussias G, Diamandis EP (2001). "Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants.". Biochem. Biophys. Res. Commun. 284 (4): 900–10. doi:10.1006/bbrc.2001.5053. PMID 11409878.
Nagano T, Yoneda T, Hatanaka Y, et al. (2002). "Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone.". Nat. Cell Biol. 4 (7): 495–501. doi:10.1038/ncb808. PMID 12055638.
Kitzig F, Martinez-Barriocanal A, López-Botet M, Sayós J (2002). "Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1.". Biochem. Biophys. Res. Commun. 296 (2): 355–62. PMID 12163025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Szafranski K, Schindler S, Taudien S, et al.. "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.