SIGIRR

From Wikipedia, the free encyclopedia

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Identifiers

SIGIRR; MGC110992; TIR8

External IDs

OMIM: 605478 MGI: 1344402 HomoloGene: 36399

Gene ontology
Molecular Function:	• transmembrane receptor activity • protein binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• negative regulation of cytokine and chemokine mediated signaling pathway • acute-phase response • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of transcription factor activity • negative regulation of chemokine biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001129013 (mRNA)
XP_001129013 (protein)

NM_023059 (mRNA)
NP_075546 (protein)

Location

Chr 11: 0.4 - 0.41 Mb

Chr 7: 140.94 - 140.95 Mb

Pubmed search

[1]

[2]

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR, is a human gene.^[1]

[edit] References

^ Entrez Gene: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.

[edit] Further reading

Thomassen E, Renshaw BR, Sims JE (1999). "Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily.". Cytokine 11 (6): 389–99. doi:10.1006/cyto.1998.0452. PMID 10346978.
Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution.". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wald D, Qin J, Zhao Z, et al. (2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Polentarutti N, Rol GP, Muzio M, et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Qin J, Qian Y, Yao J, et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.