SIAH1

From Wikipedia, the free encyclopedia

Seven in absentia homolog 1 (Drosophila)

PDB rendering based on 1k2f.

Available structures: 1k2f, 2a25, 2an6

Identifiers

Symbol(s)

SIAH1; HUMSIAH; Siah-1; Siah-1a; hSIAH1

External IDs

OMIM: 602212 MGI: 108064 HomoloGene: 20654

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• proteolysis • ubiquitin-dependent protein catabolic process • ubiquitin cycle • apoptosis • cell cycle • multicellular organismal development • spermatogenesis • nervous system development • axon guidance • anatomical structure morphogenesis • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001006610 (mRNA)
NP_001006611 (protein)

NM_009172 (mRNA)
NP_033198 (protein)

Location

Chr 16: 46.95 - 47.04 Mb

Chr 8: 89.61 - 89.64 Mb

Pubmed search

[1]

[2]

Seven in absentia homolog 1 (Drosophila), also known as SIAH1, is a human gene.

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.^[1]

[edit] References

^ Entrez Gene: SIAH1 seven in absentia homolog 1 (Drosophila).

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Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H, et al. (1996). "Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression.". Proc. Natl. Acad. Sci. U.S.A. 93 (17): 9039–42. PMID 8799150.
Hu G, Zhang S, Vidal M, et al. (1997). "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.". Genes Dev. 11 (20): 2701–14. PMID 9334332.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Hu G, Chung YL, Glover T, et al. (1998). "Characterization of human homologs of the Drosophila seven in absentia (sina) gene.". Genomics 46 (1): 103–11. doi:10.1006/geno.1997.4997. PMID 9403064.
Matsuzawa S, Takayama S, Froesch BA, et al. (1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.". EMBO J. 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. PMID 9582267.
Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3.". J. Biol. Chem. 273 (48): 31901–8. PMID 9822659.
Hu G, Fearon ER (1999). "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.". Mol. Cell. Biol. 19 (1): 724–32. PMID 9858595.
Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis.". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. doi:10.1073/pnas.040378897. PMID 10681424.
Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, et al. (2000). "p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.". J. Biol. Chem. 275 (20): 15578–85. doi:10.1074/jbc.M000372200. PMID 10747903.
Medhioub M, Vaury C, Hamelin R, Thomas G (2000). "Lack of somatic mutation in the coding sequence of SIAH1 in tumors hemizygous for this candidate tumor suppressor gene.". Int. J. Cancer 87 (6): 794–7. PMID 10956387.
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.". Oncogene 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Matsuzawa SI, Reed JC (2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.". Mol. Cell 7 (5): 915–26. PMID 11389839.
Liu J, Stevens J, Rote CA, et al. (2001). "Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.". Mol. Cell 7 (5): 927–36. PMID 11389840.
Tiedt R, Bartholdy BA, Matthias G, et al. (2001). "The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1.". EMBO J. 20 (15): 4143–52. doi:10.1093/emboj/20.15.4143. PMID 11483517.
Boehm J, He Y, Greiner A, et al. (2001). "Regulation of BOB.1/OBF.1 stability by SIAH.". EMBO J. 20 (15): 4153–62. doi:10.1093/emboj/20.15.4153. PMID 11483518.
Susini L, Passer BJ, Amzallag-Elbaz N, et al. (2002). "Siah-1 binds and regulates the function of Numb.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15067–72. doi:10.1073/pnas.261571998. PMID 11752454.
Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia.". J. Biol. Chem. 277 (12): 10273–82. doi:10.1074/jbc.M107857200. PMID 11786535.
Maeda A, Yoshida T, Kusuzaki K, Sakai T (2002). "The characterization of the human Siah-1 promoter(1).". FEBS Lett. 512 (1-3): 223–6. PMID 11852084.
Jarmuz A, Chester A, Bayliss J, et al. (2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22.". Genomics 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.