SHPRH

From Wikipedia, the free encyclopedia

SNF2 histone linker PHD RING helicase

Identifiers

SHPRH; FLJ27258; FLJ37625; FLJ45012; FLJ90837; KIAA2023; MGC134886; bA545I5.2

External IDs

OMIM: 608048 MGI: 1917581 HomoloGene: 6489

Gene ontology
Molecular Function:	• DNA binding • helicase activity • protein binding • ATP binding • zinc ion binding
Cellular Component:	• nucleosome • nucleus
Biological Process:	• nucleosome assembly • regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Refseq

NM_001042683 (mRNA)
NP_001036148 (protein)

NM_001077707 (mRNA)
NP_001071175 (protein)

Location

Chr 6: 146.23 - 146.33 Mb

Chr 10: 10.84 - 10.91 Mb

Pubmed search

[1]

[2]

SNF2 histone linker PHD RING helicase, also known as SHPRH, is a human gene.^[1]

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase.

[edit] Further reading

Motegi A, Sood R, Moinova H, et al. (2007). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.". J. Cell Biol. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMID 17130289.
Unk I, Hajdú I, Fátyol K, et al. (2007). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.". Proc. Natl. Acad. Sci. U.S.A. 103 (48): 18107–12. doi:10.1073/pnas.0608595103. PMID 17108083.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sood R, Makalowska I, Galdzicki M, et al. (2004). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.". Genomics 82 (2): 153–61. PMID 12837266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.