SHOC2

From Wikipedia, the free encyclopedia

Soc-2 suppressor of clear homolog (C. elegans)

Identifiers

SHOC2; KIAA0862; SIAA0862; SOC-2; SOC2; SUR-8; SUR8

External IDs

OMIM: 602775 MGI: 1927197 HomoloGene: 7219

Gene ontology
Molecular Function:	• molecular_function • protein binding
Cellular Component:	• cytoplasm
Biological Process:	• Ras protein signal transduction • fibroblast growth factor receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007373 (mRNA)
NP_031399 (protein)

NM_019658 (mRNA)
NP_062632 (protein)

Location

Chr 10: 112.67 - 112.76 Mb

Chr 19: 54 - 54.09 Mb

Pubmed search

[1]

[2]

Soc-2 suppressor of clear homolog (C. elegans), also known as SHOC2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans).

[edit] Further reading

Dai P, Xiong WC, Mei L (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.". J. Biol. Chem. 281 (2): 927-33. doi:10.1074/jbc.M507360200. PMID 16301319.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Li W, Han M, Guan KL (2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.". Genes Dev. 14 (8): 895-900. PMID 10783161.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355-64. PMID 10048485.
Sieburth DS, Sun Q, Han M (1998). "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.". Cell 94 (1): 119-30. PMID 9674433.
Selfors LM, Schutzman JL, Borland CZ, Stern MJ (1998). "soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6903-8. PMID 9618511.