SHC1

SHC (Src homology 2 domain containing) transforming protein 1

PDB rendering based on 1mil.

Available structures: 1mil, 1n3h, 1oy2, 1shc, 1tce

Identifiers

Symbol(s)

SHC1; FLJ26504; SHC; SHCA; p52SHC; p66; p66SHC

External IDs

Gene ontology
Molecular Function:	• transmembrane receptor protein tyrosine kinase adaptor protein activity • insulin receptor binding • insulin-like growth factor receptor binding • protein binding • phospholipid binding
Cellular Component:	• plasma membrane
Biological Process:	• activation of MAPK activity • regulation of cell growth • regulation of epidermal growth factor receptor activity • intracellular signaling cascade • positive regulation of cell proliferation • positive regulation of mitosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003029 (mRNA)
NP_003020 (protein)

NM_011368 (mRNA)
NP_035498 (protein)

Location

n/a

Pubmed search

SHC (Src homology 2 domain containing) transforming protein 1, also known as SHC1, is a human gene.

[edit] Further reading

Sasaoka T, Kobayashi M (2000). "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.". Endocr. J. 47 (4): 373–81. PMID 11075717.
Ravichandran KS (2001). "Signaling via Shc family adapter proteins.". Oncogene 20 (44): 6322–30. doi:10.1038/sj.onc.1204776. PMID 11607835.
van der Geer P (2002). "Phosphorylation of LRP1: regulation of transport and signal transduction.". Trends Cardiovasc. Med. 12 (4): 160–5. PMID 12069755.