SH3RF1

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SH3 domain containing ring finger 1
Identifiers
Symbol(s) SH3RF1; FLJ21602; KIAA1494; POSH; RNF142; SH3MD2
External IDs MGI: 1913066 HomoloGene: 10988
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57630 59009
Ensembl ENSG00000154447 ENSMUSG00000031642
Refseq NM_020870 (mRNA)
NP_065921 (protein)		 NM_198678 (mRNA)
NP_941371 (protein)
Location Chr 4: 170.25 - 170.43 Mb Chr 8: 64.12 - 64.29 Mb
Pubmed search [1] [2]

SH3 domain containing ring finger 1, also known as SH3RF1, is a human gene.[1]

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[1]

[edit] References

  1. ^ a b Entrez Gene: SH3RF1 SH3 domain containing ring finger 1.

[edit] Further reading

  • Lyons TR, Thorburn J, Ryan PW, et al. (2007). "Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.". J. Biol. Chem. 282 (30): 21987-97. doi:10.1074/jbc.M704321200. PMID 17535800. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Alroy I, Tuvia S, Greener T, et al. (2005). "The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 production.". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1478-83. doi:10.1073/pnas.0408717102. PMID 15659549. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex.". J. Biol. Chem. 278 (48): 47922-7. doi:10.1074/jbc.M307357200. PMID 14504284. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773-84. doi:10.1101/gr.406902. PMID 12421765. 
  • Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143-50. PMID 10819331. 
  • Tapon N, Nagata K, Lamarche N, Hall A (1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.". EMBO J. 17 (5): 1395-404. doi:10.1093/emboj/17.5.1395. PMID 9482736. 
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