SH3KBP1

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SH3-domain kinase binding protein 1
PDB rendering based on 1wi7.
Available structures: 1wi7, 2bz8, 2da9
Identifiers
Symbol(s) SH3KBP1; CIN85; GIG10; MIG18
External IDs OMIM: 300374 MGI: 1889583 HomoloGene: 10971
Orthologs
Human Mouse
Entrez 30011 58194
Ensembl ENSG00000147010 ENSMUSG00000040990
Uniprot Q96B97 Q3TSX2
Refseq NM_001024666 (mRNA)
NP_001019837 (protein)		 NM_021389 (mRNA)
NP_067364 (protein)
Location Chr X: 19.46 - 19.82 Mb Chr X: 154.97 - 155.32 Mb
Pubmed search [1] [2]

SH3-domain kinase binding protein 1, also known as SH3KBP1, is a human gene.

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][1]

[edit] References

  1. ^ Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1.

[edit] Further reading

  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549. 
  • Salvatore P, Hanash CR, Kido Y, et al. (1998). "Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.". J. Biol. Chem. 273 (12): 6989–97. PMID 9507006. 
  • Li J, Nishizawa K, An W, et al. (1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMID 9857189. 
  • Take H, Watanabe S, Takeda K, et al. (2000). "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.". Biochem. Biophys. Res. Commun. 268 (2): 321–8. doi:10.1006/bbrc.2000.2147. PMID 10679202. 
  • Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes.". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458. 
  • Gout I, Middleton G, Adu J, et al. (2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.". EMBO J. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMID 10921882. 
  • Watanabe S, Take H, Takeda K, et al. (2001). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes.". Biochem. Biophys. Res. Commun. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869. 
  • Borinstein SC, Hyatt MA, Sykes VW, et al. (2001). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.". Cell. Signal. 12 (11-12): 769–79. PMID 11152963. 
  • Narita T, Amano F, Yoshizaki K, et al. (2001). "Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization.". Cytogenet. Cell Genet. 93 (1-2): 133–4. PMID 11474197. 
  • Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.". Nature 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095. 
  • Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096. 
  • Scott MP, Zappacosta F, Kim EY, et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088. 
  • Verdier F, Valovka T, Zhyvoloup A, et al. (2002). "Ruk is ubiquitinated but not degraded by the proteasome.". Eur. J. Biochem. 269 (14): 3402–8. PMID 12135478. 
  • Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062. 
  • Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMID 12218189. 
  • Buchman VL, Luke C, Borthwick EB, et al. (2003). "Organization of the mouse Ruk locus and expression of isoforms in mouse tissues.". Gene 295 (1): 13–17. PMID 12242006. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tibaldi EV, Reinherz EL (2003). "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities.". Int. Immunol. 15 (3): 313–29. PMID 12618476. 
  • Hutchings NJ, Clarkson N, Chalkley R, et al. (2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.". J. Biol. Chem. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097. 
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