SH2D3C

From Wikipedia, the free encyclopedia

SH2 domain containing 3C

Identifiers

SH2D3C; CHAT; FLJ39664; NSP3; PRO34088

External IDs

OMIM: 604722 MGI: 1351631 HomoloGene: 69145

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• intracellular signaling cascade • JNK cascade • small GTPase mediated signal transduction

Orthologs

Human

Mouse

Refseq

NM_005489 (mRNA)
NP_005480 (protein)

XM_991278 (mRNA)
XP_996372 (protein)

Location

Chr 9: 129.54 - 129.58 Mb

Chr 2: 32.54 - 32.58 Mb

Pubmed search

[1]

[2]

SH2 domain containing 3C, also known as SH2D3C, is a human gene.^[1]

[edit] References

^ Entrez Gene: SH2D3C SH2 domain containing 3C.

[edit] Further reading

Near RI, Zhang Y, Makkinje A, et al. (2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.". J. Cell. Physiol. 212 (3): 655–65. doi:10.1002/jcp.21059. PMID 17427198.
Vervoort VS, Roselli S, Oshima RG, Pasquale EB (2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling.". Gene 391 (1-2): 161–70. doi:10.1016/j.gene.2006.12.016. PMID 17270363.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dail M, Kalo MS, Seddon JA, et al. (2004). "SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases.". J. Biol. Chem. 279 (40): 41892–902. doi:10.1074/jbc.M402929200. PMID 15272013.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Sakakibara A, Hattori S, Nakamura S, Katagiri T (2003). "A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells.". J. Biol. Chem. 278 (8): 6012–7. doi:10.1074/jbc.M207942200. PMID 12486027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sakakibara A, Hattori S (2000). "Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.". J. Biol. Chem. 275 (9): 6404–10. PMID 10692442.
Dodelet VC, Pazzagli C, Zisch AH, et al. (1999). "A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.". J. Biol. Chem. 274 (45): 31941–6. PMID 10542222.
Lu Y, Brush J, Stewart TA (1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway.". J. Biol. Chem. 274 (15): 10047–52. PMID 10187783.