SH2D2A

From Wikipedia, the free encyclopedia

SH2 domain protein 2A

Identifiers

SH2D2A; F2771; TSAd

External IDs

OMIM: 604514 MGI: 1351596 HomoloGene: 2958

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • protein binding
Cellular Component:	• soluble fraction • cytoplasm
Biological Process:	• angiogenesis • intracellular signaling cascade • multicellular organismal development • cell proliferation • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003975 (mRNA)
NP_003966 (protein)

NM_001025571 (mRNA)
NP_001020742 (protein)

Location

Chr 1: 155.04 - 155.05 Mb

Chr 3: 87.93 - 87.94 Mb

Pubmed search

[1]

[2]

SH2 domain protein 2A, also known as SH2D2A, is a human gene.^[1]

[edit] References

^ Entrez Gene: SH2D2A SH2 domain protein 2A.

[edit] Further reading

Marti F, Lapinski PE, King PD (2005). "The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man.". Immunol. Lett. 97 (2): 165–70. doi:10.1016/j.imlet.2004.10.019. PMID 15752554.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Spurkland A, Brinchmann JE, Markussen G, et al. (1998). "Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites.". J. Biol. Chem. 273 (8): 4539–46. PMID 9468509.
Choi YB, Kim CK, Yun Y (1999). "Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation.". J. Immunol. 163 (10): 5242–9. PMID 10553045.
Rajagopal K, Sommers CL, Decker DC, et al. (2000). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.". J. Exp. Med. 190 (11): 1657–68. PMID 10587356.
Wu LW, Mayo LD, Dunbar JD, et al. (2000). "VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.". J. Biol. Chem. 275 (9): 6059–62. PMID 10692392.
Dai KZ, Vergnaud G, Ando A, et al. (2000). "The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.". Immunogenetics 51 (3): 179–85. PMID 10752626.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Smerdel A, Dai KZ, Lorentzen AR, et al. (2005). "Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene.". Genes Immun. 5 (4): 310–2. doi:10.1038/sj.gene.6364093. PMID 15129233.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Matsumoto T, Bohman S, Dixelius J, et al. (2005). "VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.". EMBO J. 24 (13): 2342–53. doi:10.1038/sj.emboj.7600709. PMID 15962004.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Park D, Park I, Lee D, et al. (2007). "The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration.". Blood 109 (12): 5122–8. doi:10.1182/blood-2005-10-061838. PMID 17327418.