SH2D1B

From Wikipedia, the free encyclopedia

SH2 domain containing 1B

Identifiers

External IDs

OMIM: 608510 MGI: 1349420 HomoloGene: 8070

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component
Biological Process:	• intracellular signaling cascade • biological_process

Orthologs

Human

Mouse

Refseq

NM_053282 (mRNA)
NP_444512 (protein)

XM_992334 (mRNA)
XP_997428 (protein)

Location

Chr 1: 160.63 - 160.65 Mb

Chr 1: 172.11 - 172.12 Mb

Pubmed search

[1]

[2]

SH2 domain containing 1B, also known as SH2D1B, is a human gene.^[1]

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SH2D1B SH2 domain containing 1B.

[edit] Further reading

Morra M, Howie D, Grande MS, et al. (2001). "X-linked lymphoproliferative disease: a progressive immunodeficiency.". Annu. Rev. Immunol. 19: 657–82. doi:10.1146/annurev.immunol.19.1.657. PMID 11244050.
Veillette A, Latour S (2004). "The SLAM family of immune-cell receptors.". Curr. Opin. Immunol. 15 (3): 277–85. PMID 12787752.
Thompson AD, Braun BS, Arvand A, et al. (1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene.". Oncogene 13 (12): 2649–58. PMID 9000139.
Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMID 11689425.
Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.". Eur. J. Immunol. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.". J. Immunol. 177 (5): 3170–7. PMID 16920955.