SH2B3

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SH2B adaptor protein 3
Identifiers
Symbol(s) SH2B3; LNK
External IDs OMIM: 605093 MGI: 893598 HomoloGene: 36179
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10019 16923
Ensembl ENSG00000111252 ENSMUSG00000042594
Uniprot Q9UQQ2 O09039
Refseq NM_005475 (mRNA)
NP_005466 (protein)		 XM_990645 (mRNA)
XP_995739 (protein)
Location Chr 12: 110.33 - 110.37 Mb Chr 5: 122.08 - 122.1 Mb
Pubmed search [1] [2]

SH2B adaptor protein 3, also known as SH2B3, is a human gene.[1]

T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)). Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: SH2B3 SH2B adaptor protein 3.

[edit] Further reading

  • Motto DG, Musci MA, Ross SE, Koretzky GA (1996). "Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells.". Mol. Cell. Biol. 16 (6): 2823–9. PMID 8649391. 
  • Hendricks-Taylor LR, Motto DG, Zhang J, et al. (1997). "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.". J. Biol. Chem. 272 (2): 1363–7. PMID 8995445. 
  • Takaki S, Watts JD, Forbush KA, et al. (1997). "Characterization of Lnk. An adaptor protein expressed in lymphocytes.". J. Biol. Chem. 272 (23): 14562–70. PMID 9169414. 
  • Li Y, He X, Schembri-King J, et al. (2000). "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation.". J. Immunol. 164 (10): 5199–206. PMID 10799879. 
  • He X, Li Y, Schembri-King J, et al. (2001). "Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein.". Mol. Immunol. 37 (10): 603–12. PMID 11163396. 
  • Takaki S, Morita H, Tezuka Y, Takatsu K (2002). "Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk.". J. Exp. Med. 195 (2): 151–60. PMID 11805142. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Fitau J, Boulday G, Coulon F, et al. (2006). "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways.". J. Biol. Chem. 281 (29): 20148–59. doi:10.1074/jbc.M510997200. PMID 16644735. 
  • Wan M, Li Y, Xue H, et al. (2006). "TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells.". J. Surg. Res. 136 (1): 53–7. doi:10.1016/j.jss.2006.07.004. PMID 17007883. 
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