SH2B1

From Wikipedia, the free encyclopedia


SH2B adaptor protein 1
PDB rendering based on 2hdv.
Available structures: 2hdv, 2hdx
Identifiers
Symbol(s) SH2B1; DKFZp547G1110; FLJ30542; SH2-B; SH2B
External IDs OMIM: 608937 MGI1201407 HomoloGene32122
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 25970 20399
Ensembl ENSG00000178188 ENSMUSG00000030733
Refseq NM_015503 (mRNA)
NP_056318 (protein)
NM_001081459 (mRNA)
NP_001074928 (protein)
Location Chr 16: 28.77 - 28.79 Mb Chr 7: 126.26 - 126.27 Mb
Pubmed search [1] [2]

SH2B adaptor protein 1, also known as SH2B1, is a human gene.[1]


[edit] References

[edit] Further reading

  • Rui L, Mathews LS, Hotta K, et al. (1997). "Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling.". Mol. Cell. Biol. 17 (11): 6633–44. PMID 9343427. 
  • Kotani K, Wilden P, Pillay TS (1998). "SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase.". Biochem. J. 335 ( Pt 1): 103–9. PMID 9742218. 
  • Qian X, Riccio A, Zhang Y, Ginty DD (1999). "Identification and characterization of novel substrates of Trk receptors in developing neurons.". Neuron 21 (5): 1017–29. PMID 9856458. 
  • Nelms K, O'Neill TJ, Li S, et al. (2000). "Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.". Mamm. Genome 10 (12): 1160–7. PMID 10594240. 
  • Koch A, Mancini A, Stefan M, et al. (2000). "Direct interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loop.". FEBS Lett. 469 (1): 72–6. PMID 10708759. 
  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. PMID 10718198. 
  • Rui L, Gunter DR, Herrington J, Carter-Su C (2000). "Differential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbeta.". Mol. Cell. Biol. 20 (9): 3168–77. PMID 10757801. 
  • O'Brien KB, O'Shea JJ, Carter-Su C (2002). "SH2-B family members differentially regulate JAK family tyrosine kinases.". J. Biol. Chem. 277 (10): 8673–81. doi:10.1074/jbc.M109165200. PMID 11751854. 
  • Kong M, Wang CS, Donoghue DJ (2002). "Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation.". J. Biol. Chem. 277 (18): 15962–70. doi:10.1074/jbc.M102777200. PMID 11827956. 
  • Ohtsuka S, Takaki S, Iseki M, et al. (2002). "SH2-B is required for both male and female reproduction.". Mol. Cell. Biol. 22 (9): 3066–77. PMID 11940664. 
  • Xie S, Lin H, Sun T, Arlinghaus RB (2002). "Jak2 is involved in c-Myc induction by Bcr-Abl.". Oncogene 21 (47): 7137–46. doi:10.1038/sj.onc.1205942. PMID 12370803. 
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • O'Brien KB, Argetsinger LS, Diakonova M, Carter-Su C (2003). "YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.". J. Biol. Chem. 278 (14): 11970–8. doi:10.1074/jbc.M210765200. PMID 12551917. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Nishi M, Werner ED, Oh BC, et al. (2005). "Kinase activation through dimerization by human SH2-B.". Mol. Cell. Biol. 25 (7): 2607–21. doi:10.1128/MCB.25.7.2607-2621.2005. PMID 15767667. 
  • Donatello S, Fiorino A, Degl'Innocenti D, et al. (2007). "SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signaling.". Oncogene 26 (45): 6546–59. doi:10.1038/sj.onc.1210480. PMID 17471236.