SGTA

From Wikipedia, the free encyclopedia

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

Identifiers

SGTA; SGT; hSGT

External IDs

OMIM: 603419 MGI: 1098703 HomoloGene: 31122

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cellular_component • cytoplasm
Biological Process:	• protein folding • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003021 (mRNA)
NP_003012 (protein)

NM_024499 (mRNA)
NP_078775 (protein)

Location

Chr 19: 2.71 - 2.73 Mb

Chr 10: 80.45 - 80.46 Mb

Pubmed search

[1]

[2]

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha, also known as SGTA, is a human gene.^[1]

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.^[1]

[edit] References

^ ^a ^b Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha.

[edit] Further reading

Heavner GA, Audhya T, Goldstein G (1990). "Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines.". Regul. Pept. 27 (2): 257–62. PMID 2158125.
Geraghty RJ, Talbot KJ, Callahan M, et al. (1994). "Cell type-dependence for Vpu function.". J. Med. Primatol. 23 (2-3): 146–50. PMID 7966229.
Cziepluch C, Kordes E, Poirey R, et al. (1998). "Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1.". J. Virol. 72 (5): 4149–56. PMID 9557704.
Callahan MA, Handley MA, Lee YH, et al. (1998). "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family.". J. Virol. 72 (6): 5189–97. PMID 9573291.
Kordes E, Savelyeva L, Schwab M, et al. (1999). "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans.". Genomics 52 (1): 90–4. doi:10.1006/geno.1998.5385. PMID 9740675.
Callahan MA, Handley MA, Lee YH, et al. (1998). "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family.". J. Virol. 72 (10): 8461. PMID 9766974.
Liu FH, Wu SJ, Hu SM, et al. (1999). "Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats.". J. Biol. Chem. 274 (48): 34425–32. PMID 10567422.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Handley MA, Paddock S, Dall A, Panganiban AT (2002). "Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein.". Virology 291 (2): 198–207. doi:10.1006/viro.2001.1166. PMID 11878889.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Angeletti PC, Walker D, Panganiban AT (2003). "Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity.". Cell Stress Chaperones 7 (3): 258–68. PMID 12482202.
Schantl JA, Roza M, De Jong AP, Strous GJ (2003). "Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor.". Biochem. J. 373 (Pt 3): 855–63. doi:10.1042/BJ20021591. PMID 12735788.
Pai MT, Yang CS, Tzeng SR, et al. (2004). "1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT.". J. Biomol. NMR 26 (4): 381–2. PMID 12815268.
Wang H, Zhang Q, Zhu D (2004). "hSGT interacts with the N-terminal region of myostatin.". Biochem. Biophys. Res. Commun. 311 (4): 877–83. PMID 14623262.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. PMID 14667819.
Winnefeld M, Rommelaere J, Cziepluch C (2004). "The human small glutamine-rich TPR-containing protein is required for progress through cell division.". Exp. Cell Res. 293 (1): 43–57. PMID 14729056.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.