SGPP1

From Wikipedia, the free encyclopedia

Sphingosine-1-phosphate phosphatase 1

Identifiers

SGPP1; SPPase1

External IDs

Gene ontology
Molecular Function:	• hydrolase activity • sphingosine-1-phosphate phosphatase activity
Cellular Component:	• membrane fraction • endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• sphingolipid metabolic process • sphinganine-1-phosphate metabolic process • sphingosine metabolic process • apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030791 (mRNA)
NP_110418 (protein)

NM_030750 (mRNA)
NP_109675 (protein)

Location

Chr 14: 63.22 - 63.26 Mb

Chr 12: 76.63 - 76.65 Mb

Pubmed search

[1]

[2]

Sphingosine-1-phosphate phosphatase 1, also known as SGPP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SGPP1 sphingosine-1-phosphate phosphatase 1.

[edit] Further reading

Mandala SM, Thornton R, Galve-Roperh I, et al. (2000). "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7859–64. doi:10.1073/pnas.120146897. PMID 10859351.
Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003). "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2.". J. Biol. Chem. 278 (2): 1268–72. doi:10.1074/jbc.M209514200. PMID 12411432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Johnson KR, Johnson KY, Becker KP, et al. (2003). "Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.". J. Biol. Chem. 278 (36): 34541–7. doi:10.1074/jbc.M301741200. PMID 12815058.
Le Stunff H, Mikami A, Giussani P, et al. (2004). "Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis.". J. Biol. Chem. 279 (33): 34290–7. doi:10.1074/jbc.M404907200. PMID 15180992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Giussani P, Maceyka M, Le Stunff H, et al. (2006). "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.". Mol. Cell. Biol. 26 (13): 5055–69. doi:10.1128/MCB.02107-05. PMID 16782891.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.