SGK

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Serum/glucocorticoid regulated kinase
Identifiers
Symbol(s) SGK; SGK1
External IDs OMIM: 602958 MGI: 1340062 HomoloGene: 48364
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6446 20393
Ensembl ENSG00000118515 ENSMUSG00000019970
Uniprot O00141 Q3TJN4
Refseq NM_005627 (mRNA)
NP_005618 (protein)		 NM_011361 (mRNA)
NP_035491 (protein)
Location Chr 6: 134.53 - 134.68 Mb Chr 10: 21.62 - 21.69 Mb
Pubmed search [1] [2]

Serum/glucocorticoid regulated kinase, also known as SGK, is a human gene.

This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition.[1]

[edit] References

  1. ^ Entrez Gene: SGK serum/glucocorticoid regulated kinase.

[edit] Further reading

  • Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms.". Sci. STKE 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620. 
  • Waldegger S, Barth P, Raber G, Lang F (1997). "Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4440-5. PMID 9114008. 
  • Waldegger S, Erdel M, Nagl UO, et al. (1998). "Genomic organization and chromosomal localization of the human SGK protein kinase gene.". Genomics 51 (2): 299-302. doi:10.1006/geno.1998.5258. PMID 9722955. 
  • Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.". Biochem. J. 339 ( Pt 2): 319-28. PMID 10191262. 
  • Park J, Leong ML, Buse P, et al. (1999). "Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.". EMBO J. 18 (11): 3024-33. doi:10.1093/emboj/18.11.3024. PMID 10357815. 
  • Kobayashi T, Deak M, Morrice N, Cohen P (2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.". Biochem. J. 344 Pt 1: 189-97. PMID 10548550. 
  • Guan KL, Figueroa C, Brtva TR, et al. (2000). "Negative regulation of the serine/threonine kinase B-Raf by Akt.". J. Biol. Chem. 275 (35): 27354-9. doi:10.1074/jbc.M004371200. PMID 10869359. 
  • Lang F, Klingel K, Wagner CA, et al. (2000). "Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 8157-62. PMID 10884438. 
  • Brunet A, Park J, Tran H, et al. (2001). "Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).". Mol. Cell. Biol. 21 (3): 952-65. doi:10.1128/MCB.21.3.952-965.2001. PMID 11154281. 
  • Hayashi M, Tapping RI, Chao TH, et al. (2001). "BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase.". J. Biol. Chem. 276 (12): 8631-4. doi:10.1074/jbc.C000838200. PMID 11254654. 
  • Zhang BH, Tang ED, Zhu T, et al. (2001). "Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.". J. Biol. Chem. 276 (34): 31620-6. doi:10.1074/jbc.M102808200. PMID 11410590. 
  • Snyder PM, Olson DR, Thomas BC (2002). "Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.". J. Biol. Chem. 277 (1): 5-8. doi:10.1074/jbc.C100623200. PMID 11696533. 
  • Debonneville C, Flores SY, Kamynina E, et al. (2002). "Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.". EMBO J. 20 (24): 7052-9. doi:10.1093/emboj/20.24.7052. PMID 11742982. 
  • Yun CC, Chen Y, Lang F (2002). "Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2.". J. Biol. Chem. 277 (10): 7676-83. doi:10.1074/jbc.M107768200. PMID 11751930. 
  • Lizcano JM, Deak M, Morrice N, et al. (2002). "Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.". J. Biol. Chem. 277 (31): 27839-49. doi:10.1074/jbc.M202042200. PMID 12023960. 
  • Waerntges S, Klingel K, Weigert C, et al. (2003). "Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis.". Cell. Physiol. Biochem. 12 (2-3): 135-42. PMID 12077559. 
  • Busjahn A, Aydin A, Uhlmann R, et al. (2002). "Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure.". Hypertension 40 (3): 256-60. PMID 12215463. 
  • Brickley DR, Mikosz CA, Hagan CR, Conzen SD (2003). "Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1).". J. Biol. Chem. 277 (45): 43064-70. doi:10.1074/jbc.M207604200. PMID 12218062. 
  • Itani OA, Liu KZ, Cornish KL, et al. (2002). "Glucocorticoids stimulate human sgk1 gene expression by activation of a GRE in its 5'-flanking region.". Am. J. Physiol. Endocrinol. Metab. 283 (5): E971-9. doi:10.1152/ajpendo.00021.2002. PMID 12376324. 
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