SGK2

From Wikipedia, the free encyclopedia

Serum/glucocorticoid regulated kinase 2

Identifiers

SGK2; H-SGK2; dJ138B7.2

External IDs

OMIM: 607589 MGI: 1351318 HomoloGene: 8446

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein kinase CK2 activity • ATP binding • potassium channel regulator activity • transferase activity • sodium channel regulator activity
Cellular Component:	• cellular_component
Biological Process:	• protein amino acid phosphorylation • response to oxidative stress • protein kinase cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016276 (mRNA)
NP_057360 (protein)

XM_984083 (mRNA)
XP_989177 (protein)

Location

Chr 20: 41.62 - 41.65 Mb

Chr 2: 162.68 - 162.71 Mb

Pubmed search

[1]

[2]

Serum/glucocorticoid regulated kinase 2, also known as SGK2, is a human gene.^[1]

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2.

[edit] Further reading

Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms.". Sci. STKE 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620.
Kobayashi T, Deak M, Morrice N, Cohen P (2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.". Biochem. J. 344 Pt 1: 189–97. PMID 10548550.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Gamper N, Fillon S, Feng Y, et al. (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.". Pflugers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Friedrich B, Feng Y, Cohen P, et al. (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.". Pflugers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189.
Embark HM, Böhmer C, Vallon V, et al. (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms.". Pflugers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Baltaev R, Strutz-Seebohm N, Korniychuk G, et al. (2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes.". Pflugers Arch. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.