SFRS7

From Wikipedia, the free encyclopedia

Splicing factor, arginine/serine-rich 7, 35kDa

PDB rendering based on 2hvz.

Available structures: 2hvz

Identifiers

Symbol(s)

SFRS7; 9G8; AAG3; HSSG1; RBM37; ZCCHC20; ZCRB2

External IDs

OMIM: 600572 MGI: 1926232 HomoloGene: 4571

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001031684 (mRNA)
NP_001026854 (protein)

NM_146083 (mRNA)
NP_666195 (protein)

Location

Chr 2: 38.82 - 38.83 Mb

Chr 17: 80.11 - 80.12 Mb

Pubmed search

[1]

[2]

Splicing factor, arginine/serine-rich 7, 35kDa, also known as SFRS7, is a human gene.^[1]

[edit] References

^ Entrez Gene: SFRS7 splicing factor, arginine/serine-rich 7, 35kDa.

[edit] Further reading

Popielarz M, Cavaloc Y, Mattei MG, et al. (1995). "The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts.". J. Biol. Chem. 270 (30): 17830–5. PMID 7629084.
Cavaloc Y, Popielarz M, Fuchs JP, et al. (1994). "Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.". EMBO J. 13 (11): 2639–49. PMID 8013463.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Yuan Y, Li DM, Sun H (1998). "PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes.". J. Biol. Chem. 273 (32): 20347–53. PMID 9685386.
Lejeune F, Cavaloc Y, Stevenin J (2001). "Alternative splicing of intron 3 of the serine/arginine-rich protein 9G8 gene. Identification of flanking exonic splicing enhancers and involvement of 9G8 as a trans-acting factor.". J. Biol. Chem. 276 (11): 7850–8. doi:10.1074/jbc.M009510200. PMID 11096110.
Nogues G, Kadener S, Cramer P, et al. (2003). "Transcriptional activators differ in their abilities to control alternative splicing.". J. Biol. Chem. 277 (45): 43110–4. doi:10.1074/jbc.M208418200. PMID 12221105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hu D, Mayeda A, Trembley JH, et al. (2003). "CDK11 complexes promote pre-mRNA splicing.". J. Biol. Chem. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.
Yang L, Li N, Wang C, et al. (2004). "Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.". J. Biol. Chem. 279 (12): 11639–48. doi:10.1074/jbc.M312895200. PMID 14684736.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ropers D, Ayadi L, Gattoni R, et al. (2004). "Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA.". J. Biol. Chem. 279 (29): 29963–73. doi:10.1074/jbc.M404452200. PMID 15123677.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.". RNA 10 (6): 929–41. PMID 15146077.
Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
Lai MC, Tarn WY (2004). "Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins.". J. Biol. Chem. 279 (30): 31745–9. doi:10.1074/jbc.C400173200. PMID 15184380.
Huang Y, Yario TA, Steitz JA (2004). "A molecular link between SR protein dephosphorylation and mRNA export.". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9666–70. doi:10.1073/pnas.0403533101. PMID 15210956.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Jacquenet S, Decimo D, Muriaux D, Darlix JL (2006). "Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production.". Retrovirology 2: 33. doi:10.1186/1742-4690-2-33. PMID 15907217.