SFRS6

From Wikipedia, the free encyclopedia

Splicing factor, arginine/serine-rich 6

Identifiers

SFRS6; B52; MGC5045; SRP55

External IDs

OMIM: 601944 MGI: 1915246 HomoloGene: 74570

Gene ontology
Molecular Function:	• nucleotide binding • RNA binding
Cellular Component:	• nucleus
Biological Process:	• mRNA splice site selection • mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_006275 (mRNA)
NP_006266 (protein)

XM_980333 (mRNA)
XP_985427 (protein)

Location

Chr 20: 41.52 - 41.53 Mb

Chr 2: 162.62 - 162.63 Mb

Pubmed search

[1]

[2]

Splicing factor, arginine/serine-rich 6, also known as SFRS6, is a human gene.^[1]

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.^[1]

[edit] References

^ ^a ^b Entrez Gene: SFRS6 splicing factor, arginine/serine-rich 6.

[edit] Further reading

Zahler AM, Lane WS, Stolk JA, Roth MB (1992). "SR proteins: a conserved family of pre-mRNA splicing factors.". Genes Dev. 6 (5): 837–47. PMID 1577277.
Screaton GR, Cáceres JF, Mayeda A, et al. (1995). "Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.". EMBO J. 14 (17): 4336–49. PMID 7556075.
Ramchatesingh J, Zahler AM, Neugebauer KM, et al. (1995). "A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer.". Mol. Cell. Biol. 15 (9): 4898–907. PMID 7651409.
Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle.". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
Nagel RJ, Lancaster AM, Zahler AM (1998). "Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55.". RNA 4 (1): 11–23. PMID 9436904.
Liu HX, Zhang M, Krainer AR (1998). "Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins.". Genes Dev. 12 (13): 1998–2012. PMID 9649504.
Lemaire R, Winne A, Sarkissian M, Lafyatis R (1999). "SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation.". Eur. J. Immunol. 29 (3): 823–37. PMID 10092085.
Paillard F (1999). "A novel soluble chimera for the treatment of familial hypercholesterolemia.". Hum. Gene Ther. 10 (7): 1093–4. doi:10.1089/10430349950018085. PMID 10340541.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.". Mol. Cell. Biol. 20 (9): 3049–57. PMID 10757789.
Monsalve M, Wu Z, Adelmant G, et al. (2000). "Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.". Mol. Cell 6 (2): 307–16. PMID 10983978.
Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20.". Genomics 76 (1-3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer.". Biochim. Biophys. Acta 1625 (2): 141–52. PMID 12531473.
Tran Q, Roesser JR (2003). "SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing.". Biochemistry 42 (4): 951–7. doi:10.1021/bi026753a. PMID 12549914.
Lai MC, Lin RI, Tarn WY (2003). "Differential effects of hyperphosphorylation on splicing factor SRp55.". Biochem. J. 371 (Pt 3): 937–45. doi:10.1042/BJ20021827. PMID 12549978.
Pind MT, Watson PH (2004). "SR protein expression and CD44 splicing pattern in human breast tumours.". Breast Cancer Res. Treat. 79 (1): 75–82. PMID 12779084.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. PMID 14559993.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.