SFRS12

From Wikipedia, the free encyclopedia

Splicing factor, arginine/serine-rich 12

Identifiers

SFRS12; DKFZp564B176; MGC133045; SRrp508; SRrp86

External IDs

OMIM: 609268 MGI: 2145245 HomoloGene: 10581

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding
Cellular Component:	• nucleus • spliceosome
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001077199 (mRNA)
NP_001070667 (protein)

NM_172592 (mRNA)
NP_766180 (protein)

Location

Chr 5: 65.48 - 65.52 Mb

Chr 13: 104.86 - 104.88 Mb

Pubmed search

[1]

[2]

Splicing factor, arginine/serine-rich 12, also known as SFRS12, is a human gene.^[1]

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12.

[edit] Further reading

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.". J. Mol. Neurosci. 24 (2): 269-76. PMID 15456940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437-47. PMID 14559993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA.". RNA 8 (10): 1334-47. PMID 12403470.
Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor.". J. Biol. Chem. 277 (42): 39485-92. doi:10.1074/jbc.M201784200. PMID 12183448.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome.". Genome Res. 12 (8): 1231-45. doi:10.1101/gr.473902. PMID 12176931.
Zhang DL, Sun XJ, Ling LJ, et al. (2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao 29 (5): 377-83. PMID 12043562.
Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.". RNA 8 (4): 526-33. PMID 11991645.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.". Mol. Cell. Biol. 20 (9): 3049-57. PMID 10757789.