SFRS11

From Wikipedia, the free encyclopedia

Splicing factor, arginine/serine-rich 11

Identifiers

SFRS11; DKFZp686M13204; dJ677H15.2; p54

External IDs

OMIM: 602010 MGI: 1916457 HomoloGene: 36164

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding
Cellular Component:	• nucleus
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004768 (mRNA)
NP_004759 (protein)

NM_026989 (mRNA)
NP_081265 (protein)

Location

Chr 1: 70.44 - 70.49 Mb

Chr 3: 157.95 - 157.97 Mb

Pubmed search

[1]

[2]

Splicing factor, arginine/serine-rich 11, also known as SFRS11, is a human gene.^[1]

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.^[1]

[edit] References

^ ^a ^b Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11.

[edit] Further reading

Chaudhary N, McMahon C, Blobel G (1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components.". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8189–93. PMID 1896467.
Zhang WJ, Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing.". Mol. Cell. Biol. 16 (10): 5400–8. PMID 8816452.
Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.". J. Biol. Chem. 273 (41): 26261–4. PMID 9756848.
Page-McCaw PS, Amonlirdviman K, Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity.". RNA 5 (12): 1548–60. PMID 10606266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.". Mol. Cell. Biol. 24 (3): 1174–87. PMID 14729963.
Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMID 16943417.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.