SF1 (gene)

From Wikipedia, the free encyclopedia

Splicing factor 1

PDB rendering based on 1k1g.

Available structures: 1k1g

Identifiers

Symbol(s)

SF1; D11S636; ZFM1; ZNF162

External IDs

OMIM: 601516 MGI: 1095403 HomoloGene: 6461

Gene ontology
Molecular Function:	• RNA polymerase II transcription factor activity • transcription corepressor activity • RNA binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • spliceosome • ribosome
Biological Process:	• spliceosome assembly • nuclear mRNA 3'-splice site recognition • transcription • regulation of transcription, DNA-dependent • biological_process • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004630 (mRNA)
NP_004621 (protein)

XM_979802 (mRNA)
XP_984896 (protein)

Location

Chr 11: 64.29 - 64.3 Mb

Chr 19: 6.36 - 6.38 Mb

Pubmed search

[1]

[2]

Splicing factor 1, also known as SF1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SF1 splicing factor 1.

[edit] Further reading

Krämer A (1992). "Purification of splicing factor SF1, a heat-stable protein that functions in the assembly of a presplicing complex.". Mol. Cell. Biol. 12 (10): 4545–52. PMID 1406644.
Toda T, Iida A, Miwa T, et al. (1994). "Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).". Hum. Mol. Genet. 3 (3): 465–70. PMID 7912130.
Naumovski L, Cleary ML (1996). "The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M.". Mol. Cell. Biol. 16 (7): 3884–92. PMID 8668206.
Arning S, Grüter P, Bilbe G, Krämer A (1996). "Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.". RNA 2 (8): 794–810. PMID 8752089.
Abovich N, Rosbash M (1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals.". Cell 89 (3): 403–12. PMID 9150140.
Caslini C, Spinelli O, Cazzaniga G, et al. (1997). "Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins.". Genomics 42 (2): 268–77. doi:10.1006/geno.1997.4705. PMID 9192847.
Zhang D, Childs G (1998). "Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage-specific activator protein.". J. Biol. Chem. 273 (12): 6868–77. PMID 9506990.
Berglund JA, Abovich N, Rosbash M (1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition.". Genes Dev. 12 (6): 858–67. PMID 9512519.
Krämer A, Quentin M, Mulhauser F (1998). "Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene.". Gene 211 (1): 29–37. PMID 9573336.
Zhang D, Paley AJ, Childs G (1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.". J. Biol. Chem. 273 (29): 18086–91. PMID 9660765.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Wang X, Bruderer S, Rafi Z, et al. (1999). "Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.". EMBO J. 18 (16): 4549–59. doi:10.1093/emboj/18.16.4549. PMID 10449420.
Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray.". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. doi:10.1006/bbrc.2001.5215. PMID 11467860.
Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1.". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMID 11604498.
Liu Z, Luyten I, Bottomley MJ, et al. (2001). "Structural basis for recognition of the intron branch site RNA by splicing factor 1.". Science 294 (5544): 1098–102. doi:10.1126/science.1064719. PMID 11691992.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome.". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMID 12176931.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Selenko P, Gregorovic G, Sprangers R, et al. (2003). "Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.". Mol. Cell 11 (4): 965–76. PMID 12718882.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMID 15456888.