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Depression (Part 1) Guest Editors: John H. Kehne and Ronald S. Duman (April 07)
New approaches to antidepressant drug discovery: beyond monoamines. Olivier Berton and Eric J. Nestler
The Genetics of Depression: A Review (Jul '06)
The Mesolimbic Dopamine Reward Circuit in Depression (Jun 06)
Serotonin Receptors as Targets in Drug Discovery and Medicinal Chemistry (Sep '06)
Serotonin-Dopamine Interaction as a Focus of Novel Antidepressant Drugs (feb 06)
Neurotransmitter transporters and their impact on the development of psychopharmacology. Iversen Br J Pharmacol 147: S82-S88 2006
Serotonin Reuptake Inhibitors: The Corner Stone in Treatment of Depression for Half a Century - A Medicinal Chemistry Survey.
Serotonin (5HT), Fluoxetine, Imipramine and Dopamine Target Distinct 5HT Receptor Signaling to Modulate Caenorhabditis elegans Egg-Laying Behavior Ji Ying Sze1 2005
[edit] Neuronal Targets of Cocaine
[edit] Dopamine
Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement (2007) J. Dalley
Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys. (2007)
D2-Autoreceptors Chronically Enhance Dopamine Neuron Pacemaker Activity J Neurosci 2006 May 10; 26(19): 5240–5247.
Cooperative activation of D1- and D2-like DA receptors in the NAc shell is required for cocaine-seeking behavior in the rat (06) H.D. Schmidt
Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction (2006)
Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys. Synapse, 56:129-134, 2005.
Dopamine and drug addiction: the nucleus accumbens shell connection. Gaetano Di Chiara, Valentina Bassareoa, Sandro Fenua, Maria Antonietta De Lucaa, Liliana Spinaa, Cristina Cadonia, Elio Acquasa, Ezio Carbonia, Valentina Valentinia and Daniele Leccaa 2004.
[edit] N-Epinephrine
Difference in magnitude of psychostimulant-induced extracellular norepinephrine in the ventral tegmental area contributes to discrepant prefrontal dopamine outflow Pan WH, Hsieh MC, Wu HH, Lin SK. Addict Biol. 2007 Mar;12(1):51-8.
Alpha-Noradrenergic Receptors Modulate the Development and Expression of Cocaine Sensitization (2006).
Role of the increased noradrenergic neurotransmission in drug self-administration. Wee S, Wang Z, He R, Zhou J, Kozikowski AP, Woolverton WL. 2005
Neurochemical interaction between dopaminergic and noradrenergic neurons in the medial prefrontal cortex Wynn Pan, Sze-Yuan Yang, Shi-Kwang Lin
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Gainetdinov 2000
Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys (95 Spealman)
[edit] Serotonin
Effects of Combined Dopamine and Serotonin Transporter Inhibitors on Cocaine Self-Administration in Rhesus Monkeys. (2007)
Development of a Rationally Designed, Low Abuse Potential, Biogenic Amine Releaser That Suppresses Cocaine Self-Administration ('05)
Relationship between the Serotonergic Activity and Reinforcing Effects of a Series of Amphetamine Analogs (2005)
Role of serotonin in cocaine effects in mice with reduced dopamine transporter function. PNAS, January 6, 2004; 101(1): 372-377.
Serotonin1B Receptors in the Ventral Tegmental Area Modulate Cocaine-Induced Increases in Nucleus Accumbens Dopamine Levels 04
Serotonergic Attenuation of the Reinforcing and Neurochemical Effects of Cocaine in Squirrel Monkeys. JPET 2002 300: 831-837.
The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant. Ronald B.P. Jobe 2005
[edit] σ–Receptors
σ Receptors: potential medications development target for anti-cocaine agents (03) Matsumoto
Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides R. Matsumoto, K. McCracken (2002).
[edit] Cholinergic
Pharmacological Characterization of Nicotine's Interaction with Cocaine and Cocaine Analogs J Pharmacol Exp Ther 1999 289: 1229-1236.
Ritz* Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality '97
Ritz* Cocaine-induced convulsions: pharmacological antagonism at serotonergic, muscarinic and sigma receptors '97
[edit] Na+ Channels
In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys. (2005)
On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys. (2000)
[edit] Ionotropic Glutamate Receptors
AMPA and NMDA Receptors in P2 Fractions of Cocaine and Cocaine–Prazosin-Treated Rats August 2006
Reduction of Corticostriatal Glutamatergic Fibers in Basic Fibroblast Growth Factor Deficient Mice is Associated with Hyperactivity and Enhanced Dopaminergic Transmission Dec 2006
Repeated cocaine administration differentially affects NMDA receptor subunit (NR1, NR2A-C) mRNAs in rat brain Mika Yamaguchi 1 2, Toshihito Suzuki 1 2 *, Shuzo Abe 2, Takafumi Hori 2, Hirofumi Kurita 2, Takashi Asada 2, Nobuo Okado 3, Heii Arai '02
