Serotonin uptake inhibitor

From Wikipedia, the free encyclopedia

A serotonin uptake inhibitor is a drug which acts as a neurotransmitter uptake inhibitor on serotonin receptors.

Contents 1 Types 2 Examples 3 References 4 External links

[edit] Types

The most well known members of this class are the selective serotonin reuptake inhibitors (SSRI)s.

However, there also exist non-selective inhibitors. In some cases, such as the older antidepressants clomipramine and trazodone, this lack of selectivity is seen as a disadvantage, and is one of the reasons those drugs are currently prescribed less frequently.

In other cases, such as duloxetine and milnacipran, the lack of selectivity is considered part of the normal profile of the medication, and it is classified accordingly.

[edit] Examples

Examples of serotonin uptake inhibitors include:^[1]

• alaproclate
• amoxapine
• citalopram
• clomipramine
• duloxetine
• femoxetine
• fluoxetine
• fluvoxamine
• indalpine
• milnacipran
• paroxetine
• sertraline
• trazodone
• venlafaxine
• zimeldine

[edit] References

1. ^ MeSH list of agents 82017367

[edit] External links

• MeSH Serotonin+uptake+inhibitors

v • d • e Receptor agonists, antagonists, and reuptake inhibitors BA/M: 5-HT (serotonin) receptor Serotonin receptor agonist • Serotonin antagonist (5-HT3) • Serotonin uptake inhibitor (SSRI) BA/M: Dopamine receptor Dopamine agonist • Dopamine antagonist • Dopamine reuptake inhibitor BA/M: Adrenergic receptor Adrenergic agonist (Alpha, Beta2) • Adrenergic antagonist (Alpha, Beta) • Adrenergic uptake inhibitor BA/M: Histamine receptor Histamine agonist • Histamine antagonist (H1, H2) Acetylcholine receptor Cholinergic (Muscarinic, Nicotinic) • Anticholinergic (Muscarinic, Nicotinic) • Acetylcholinesterase inhibitor AA: GABA receptor GABA agonist • GABA antagonist AA: Glutamate receptor NMDA receptor (NMDA receptor antagonist)

v • d • e Psychoanaleptics: antidepressants (N06A) MAOIs Iproclozide • Iproniazid • Isocarboxazid • Minaprine • Nialamide • Pargyline • Phenelzine • Rasagiline • Selegiline • Toloxatone • Tranylcypromine RIMAs: Befloxatone • Brofaromine • Cimoxatone • Beta-carbolines (Harmaline) • Moclobemide RIs S RI SS RI (Alaproclate, Citalopram, Dapoxetine, Escitalopram, Femoxetine, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine) • TCAs/Tetras (Clomipramine, Nefazodone, Trazodone) N RI / A RI Atomoxetine • Maprotiline • Nisoxetine • Reboxetine • Talopram • Viloxazine • TCAs/Tetras (Amitriptyline, Amoxapine, Butriptyline, Desipramine/Lofepramine, Dibenzepin, Dosulepin, Doxepin, Imipramine, Iprindole, Melitracen, Nortriptyline, Protriptyline, Trimipramine, Maprotiline) D RI Medifoxamine • Phenmetrazine • Vanoxerine • TCAs (Amineptine) SN RI Bicifadine • Desvenlafaxine • Duloxetine • Milnacipran • Nefazodone • Venlafaxine ND RI Bupropion • Nomifensine SND RI Brasofensine • Diclofensine • Tesofensine SSREs Tianeptine AAs Tetras (Mianserin, Mirtazapine)