Serine-glyoxylate transaminase

From Wikipedia, the free encyclopedia

In enzymology, a serine-glyoxylate transaminase (EC 2.6.1.45) is an enzyme that catalyzes the chemical reaction

L-serine + glyoxylate 3-hydroxypyruvate + glycine

Thus, the two substrates of this enzyme are L-serine and glyoxylate, whereas its two products are 3-hydroxypyruvate and glycine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-serine:glyoxylate aminotransferase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

[edit] References

• IUBMB entry for 2.6.1.45
• BRENDA references for 2.6.1.45 (Recommended.)
• PubMed references for 2.6.1.45
• PubMed Central references for 2.6.1.45
• Google Scholar references for 2.6.1.45
• Ireland RJ, Joy KW (1983). "Purification and properties of an asparagine aminotransferase from Pisum sativum leaves". Arch. Biochem. Biophys. 223: 291–6. doi:10.1016/0003-9861(83)90594-5. PMID 6407397. 
• King J, Waygood ER (1968). "Glyoxylate aminotranferases from wheat leaves". Can. J. Biochem. 46: 771–9. PMID 5672858. 
• Smith IK (1973). "Purification and characterization of serine:glyoxylate aminotransferase from kidney bean (Phaseolus vulgaris)". Biochim. Biophys. Acta. 321: 156–64. PMID 4750762. 

[edit] External links

The CAS registry number for this enzyme class is 37259-57-7.

• IUBMB entry for 2.6.1.45

• KEGG entry for 2.6.1.45

• BRENDA entry for 2.6.1.45

• NiceZyme view of 2.6.1.45

• EC2PDB: PDB structures for 2.6.1.45

• PRIAM entry for 2.6.1.45

• PUMA2 entry for 2.6.1.45

• IntEnz: Integrated Enzyme entry for 2.6.1.45

• MetaCyc entry for 2.6.1.45

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050281: serine-glyoxylate transaminase

• AMIGO entry for GO code 0050281: serine-glyoxylate transaminase