SERPINI1

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Serpin peptidase inhibitor, clade I (neuroserpin), member 1
PDB rendering based on 1jjo.
Available structures: 1jjo
Identifiers
Symbol(s) SERPINI1; DKFZp781N13156; PI12; neuroserpin
External IDs OMIM: 602445 MGI: 1194506 HomoloGene: 21045
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5274 20713
Ensembl ENSG00000163536 ENSMUSG00000027834
Uniprot Q99574 O35684
Refseq NM_005025 (mRNA)
NP_005016 (protein)		 NM_009250 (mRNA)
NP_033276 (protein)
Location Chr 3: 168.94 - 169.03 Mb Chr 3: 75.64 - 75.73 Mb
Pubmed search [1] [2]

Serpin peptidase inhibitor, clade I (neuroserpin), member 1, also known as SERPINI1, is a human gene.[1]

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1.

[edit] Further reading

  • Yepes M, Lawrence DA (2004). "Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system.". Thromb. Haemost. 91 (3): 457–64. doi:10.1160/TH03-12-0766. PMID 14983220. 
  • Schrimpf SP, Bleiker AJ, Brecevic L, et al. (1997). "Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26.". Genomics 40 (1): 55–62. doi:10.1006/geno.1996.4514. PMID 9070919. 
  • Hastings GA, Coleman TA, Haudenschild CC, et al. (1998). "Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival.". J. Biol. Chem. 272 (52): 33062–7. PMID 9407089. 
  • Davis RL, Shrimpton AE, Holohan PD, et al. (1999). "Familial dementia caused by polymerization of mutant neuroserpin.". Nature 401 (6751): 376–9. doi:10.1038/43894. PMID 10517635. 
  • Chang WS, Chang NT, Lin SC, et al. (2000). "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26.". Genes Chromosomes Cancer 29 (3): 240–55. PMID 10992299. 
  • Belorgey D, Crowther DC, Mahadeva R, Lomas DA (2002). "Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro.". J. Biol. Chem. 277 (19): 17367–73. doi:10.1074/jbc.M200680200. PMID 11880376. 
  • Davis RL, Shrimpton AE, Carrell RW, et al. (2002). "Association between conformational mutations in neuroserpin and onset and severity of dementia.". Lancet 359 (9325): 2242–7. PMID 12103288. 
  • Barker-Carlson K, Lawrence DA, Schwartz BS (2003). "Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro.". J. Biol. Chem. 277 (49): 46852–7. doi:10.1074/jbc.M207740200. PMID 12228252. 
  • Parmar PK, Coates LC, Pearson JF, et al. (2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells.". J. Neurochem. 82 (6): 1406–15. PMID 12354288. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Miranda E, Römisch K, Lomas DA (2004). "Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum.". J. Biol. Chem. 279 (27): 28283–91. doi:10.1074/jbc.M313166200. PMID 15090543. 
  • Teesalu T, Kulla A, Simisker A, et al. (2005). "Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system.". Thromb. Haemost. 92 (2): 358–68. doi:10.1267/THRO04080358. PMID 15269833. 
  • Belorgey D, Sharp LK, Crowther DC, et al. (2004). "Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB.". Eur. J. Biochem. 271 (16): 3360–7. doi:10.1111/j.1432-1033.2004.04270.x. PMID 15291813. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Onda M, Belorgey D, Sharp LK, Lomas DA (2005). "Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies.". J. Biol. Chem. 280 (14): 13735–41. doi:10.1074/jbc.M413282200. PMID 15664988. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kinghorn KJ, Crowther DC, Sharp LK, et al. (2006). "Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.". J. Biol. Chem. 281 (39): 29268–77. doi:10.1074/jbc.M600690200. PMID 16849336. 
  • Chen PY, Chang WS, Chou RH, et al. (2007). "Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner.". BMC Mol. Biol. 8: 2. doi:10.1186/1471-2199-8-2. PMID 17212813. 
  • Gourfinkel-An I, Duyckaerts C, Camuzat A, et al. (2007). "Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene.". Neurology 69 (1): 79–83. doi:10.1212/01.wnl.0000265052.99144.b5. PMID 17606885. 
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