SERPINF1

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Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
PDB rendering based on 1imv.
Available structures: 1imv
Identifiers
Symbol(s) SERPINF1; EPC-1; PEDF; PIG35
External IDs OMIM: 172860 MGI: 108080 HomoloGene: 1965
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 5176 20317
Ensembl ENSG00000132386 ENSMUSG00000000753
Uniprot P36955 Q5ND38
Refseq NM_002615 (mRNA)
NP_002606 (protein)		 NM_011340 (mRNA)
NP_035470 (protein)
Location Chr 17: 1.61 - 1.63 Mb Chr 11: 75.23 - 75.24 Mb
Pubmed search [1] [2]

Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1, also known as SERPINF1, is a human gene.[1]


Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1.

[edit] Further reading

  • Tong JP, Yao YF (2006). "Contribution of VEGF and PEDF to choroidal angiogenesis: a need for balanced expressions.". Clin. Biochem. 39 (3): 267–76. doi:10.1016/j.clinbiochem.2005.11.013. PMID 16409998. 
  • Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098. 
  • Becerra SP, Sagasti A, Spinella P, Notario V (1995). "Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop.". J. Biol. Chem. 270 (43): 25992–9. PMID 7592790. 
  • Tombran-Tink J, Pawar H, Swaroop A, et al. (1994). "Localization of the gene for pigment epithelium-derived factor (PEDF) to chromosome 17p13.1 and expression in cultured human retinoblastoma cells.". Genomics 19 (2): 266–72. doi:10.1006/geno.1994.1057. PMID 8188257. 
  • Becerra SP, Palmer I, Kumar A, et al. (1993). "Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli. A functionally active neurotrophic factor.". J. Biol. Chem. 268 (31): 23148–56. PMID 8226833. 
  • Steele FR, Chader GJ, Johnson LV, Tombran-Tink J (1993). "Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family.". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1526–30. PMID 8434014. 
  • Pignolo RJ, Cristofalo VJ, Rotenberg MO (1993). "Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state.". J. Biol. Chem. 268 (12): 8949–57. PMID 8473338. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Ortego J, Escribano J, Becerra SP, Coca-Prados M (1997). "Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor.". Invest. Ophthalmol. Vis. Sci. 37 (13): 2759–67. PMID 8977492. 
  • Tombran-Tink J, Mazuruk K, Rodriguez IR, et al. (1998). "Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin.". Mol. Vis. 2: 11. PMID 9238088. 
  • Alberdi E, Hyde CC, Becerra SP (1998). "Pigment epithelium-derived factor (PEDF) binds to glycosaminoglycans: analysis of the binding site.". Biochemistry 37 (30): 10643–52. doi:10.1021/bi9802317. PMID 9692954. 
  • Dawson DW, Volpert OV, Gillis P, et al. (1999). "Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.". Science 285 (5425): 245–8. PMID 10398599. 
  • Koenekoop R, Pina AL, Loyer M, et al. (1999). "Four polymorphic variations in the PEDF gene identified during the mutation screening of patients with Leber congenital amaurosis.". Mol. Vis. 5: 10. PMID 10398730. 
  • Alberdi E, Aymerich MS, Becerra SP (1999). "Binding of pigment epithelium-derived factor (PEDF) to retinoblastoma cells and cerebellar granule neurons. Evidence for a PEDF receptor.". J. Biol. Chem. 274 (44): 31605–12. PMID 10531367. 
  • Karakousis PC, John SK, Behling KC, et al. (2001). "Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues.". Mol. Vis. 7: 154–63. PMID 11438800. 
  • Simonovic M, Gettins PG, Volz K (2001). "Crystal structure of human PEDF, a potent anti-angiogenic and neurite growth-promoting factor.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11131–5. doi:10.1073/pnas.211268598. PMID 11562499. 
  • Yamagishi S, Inagaki Y, Amano S, et al. (2002). "Pigment epithelium-derived factor protects cultured retinal pericytes from advanced glycation end product-induced injury through its antioxidative properties.". Biochem. Biophys. Res. Commun. 296 (4): 877–82. PMID 12200129. 
  • Meyer C, Notari L, Becerra SP (2003). "Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity.". J. Biol. Chem. 277 (47): 45400–7. doi:10.1074/jbc.M208339200. PMID 12237317. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Pignolo RJ, Francis MK, Rotenberg MO, Cristofalo VJ (2003). "Putative role for EPC-1/PEDF in the G0 growth arrest of human diploid fibroblasts.". J. Cell. Physiol. 195 (1): 12–20. doi:10.1002/jcp.10212. PMID 12599204. 

[edit] External links

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Serpins
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Cross class inhibitory
MENT · SCCA-1 · crmA
noninhibitory