SEPW1

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Selenoprotein W, 1
Identifiers
Symbol(s) SEPW1; selW
External IDs OMIM: 603235 MGI: 1100878 HomoloGene: 2263
Orthologs
Human Mouse
Entrez 6415 20364
Ensembl n/a ENSMUSG00000041571
Uniprot n/a P63300
Refseq NM_003009 (mRNA)
NP_003000 (protein)		 NM_009156 (mRNA)
NP_033182 (protein)
Location n/a Chr 7: 15.08 - 15.08 Mb
Pubmed search [1] [2]

Selenoprotein W, 1, also known as SEPW1, is a human gene.[1]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.[1]

[edit] References

  1. ^ a b Entrez Gene: SEPW1 selenoprotein W, 1.

[edit] Further reading

  • Whanger PD (2001). "Selenoprotein W: a review.". Cell. Mol. Life Sci. 57 (13-14): 1846-52. PMID 11215511. 
  • Yeh JY, Beilstein MA, Andrews JS, Whanger PD (1995). "Tissue distribution and influence of selenium status on levels of selenoprotein W.". FASEB J. 9 (5): 392-6. PMID 7896009. 
  • Gu QP, Beilstein MA, Vendeland SC, et al. (1997). "Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species.". Gene 193 (2): 187-96. PMID 9256076. 
  • Smith JS, Tachibana I, Pohl U, et al. (2000). "A transcript map of the chromosome 19q-arm glioma tumor suppressor region.". Genomics 64 (1): 44-50. doi:10.1006/geno.1999.6101. PMID 10708517. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Kryukov GV, Castellano S, Novoselov SV, et al. (2003). "Characterization of mammalian selenoproteomes.". Science 300 (5624): 1439-43. doi:10.1126/science.1083516. PMID 12775843. 
  • Bellingham J, Gregory-Evans K, Fox MF, Gregory-Evans CY (2003). "Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P.". Biochim. Biophys. Acta 1627 (2-3): 140-6. PMID 12818432. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Pagmantidis V, Bermano G, Villette S, et al. (2005). "Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon.". FEBS Lett. 579 (3): 792-6. doi:10.1016/j.febslet.2004.12.042. PMID 15670848. 
  • Kim YJ, Chai YG, Ryu JC (2005). "Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion.". Biochem. Biophys. Res. Commun. 330 (4): 1095-102. doi:10.1016/j.bbrc.2005.03.080. PMID 15823556. 
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