SEPT9

From Wikipedia, the free encyclopedia

Septin 9

Identifiers

SEPT9; MSF; AF17q25; KIAA0991; MSF1; NAPB; PNUTL4; SINT1

External IDs

OMIM: 604061 MGI: 1858222 HomoloGene: 4838

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular Component:	• stress fiber • cytoplasm • microtubule • membrane • perinuclear region of cytoplasm
Biological Process:	• cell cycle • negative regulation of progression through cell cycle • protein heterooligomerization • cell division

Orthologs

Human

Mouse

Refseq

NM_006640 (mRNA)
NP_006631 (protein)

NM_017380 (mRNA)
NP_059076 (protein)

Location

Chr 17: 72.91 - 73.01 Mb

Chr 11: 117.02 - 117.18 Mb

Pubmed search

[1]

[2]

Septin 9, also known as SEPT9, is a human gene.^[1]

[edit] References

^ Entrez Gene: SEPT9 septin 9.

[edit] Further reading

Pellegrino JE, George RA, Biegel J, et al. (1998). "Hereditary neuralgic amyotrophy: evidence for genetic homogeneity and mapping to chromosome 17q25.". Hum. Genet. 101 (3): 277–83. PMID 9439655.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.
Osaka M, Rowley JD, Zeleznik-Le NJ (1999). "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6428–33. PMID 10339604.
Taki T, Ohnishi H, Shinohara K, et al. (1999). "AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25).". Cancer Res. 59 (17): 4261–5. PMID 10485469.
Medina M, Marinescu RC, Overhauser J, Kosik KS (2000). "Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome.". Genomics 63 (2): 157–64. doi:10.1006/geno.1999.6090. PMID 10673328.
Kalikin LM, Sims HL, Petty EM (2000). "Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors.". Genomics 63 (2): 165–72. doi:10.1006/geno.1999.6077. PMID 10673329.
Russell SE, McIlhatton MA, Burrows JF, et al. (2000). "Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.". Cancer Res. 60 (17): 4729–34. PMID 10987277.
McIlhatton MA, Burrows JF, Donaghy PG, et al. (2001). "Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3.". Oncogene 20 (41): 5930–9. doi:10.1038/sj.onc.1204752. PMID 11593400.
Yamamoto K, Shibata F, Yamaguchi M, Miura O (2003). "Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25).". Int. J. Hematol. 75 (5): 503–7. PMID 12095151.
Surka MC, Tsang CW, Trimble WS (2003). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis.". Mol. Biol. Cell 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMID 12388755.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nagata K, Kawajiri A, Matsui S, et al. (2003). "Filament formation of MSF-A, a mammalian septin, in human mammary epithelial cells depends on interactions with microtubules.". J. Biol. Chem. 278 (20): 18538–43. doi:10.1074/jbc.M205246200. PMID 12626509.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Nagata K, Asano T, Nozawa Y, Inagaki M (2005). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.". J. Biol. Chem. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Scott M, Hyland PL, McGregor G, et al. (2005). "Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours.". Oncogene 24 (29): 4688–700. doi:10.1038/sj.onc.1208574. PMID 15782116.
Ito H, Iwamoto I, Morishita R, et al. (2005). "Possible role of Rho/Rhotekin signaling in mammalian septin organization.". Oncogene 24 (47): 7064–72. doi:10.1038/sj.onc.1208862. PMID 16007136.
Scott M, McCluggage WG, Hillan KJ, et al. (2006). "Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis.". Int. J. Cancer 118 (5): 1325–9. doi:10.1002/ijc.21486. PMID 16161048.
Kuhlenbäumer G, Hannibal MC, Nelis E, et al. (2005). "Mutations in SEPT9 cause hereditary neuralgic amyotrophy.". Nat. Genet. 37 (10): 1044–6. doi:10.1038/ng1649. PMID 16186812.