SEPT3

From Wikipedia, the free encyclopedia

Septin 3

Identifiers

SEPT3; MGC133218; SEP3; bK250D10.3

External IDs

OMIM: 608314 MGI: 1345148 HomoloGene: 56544

Gene ontology
Molecular Function:	• nucleotide binding • molecular_function • GTP binding
Cellular Component:	• cellular_component
Biological Process:	• cytokinesis • cell cycle

Orthologs

Human

Mouse

Refseq

NM_019106 (mRNA)
NP_061979 (protein)

NM_011889 (mRNA)
NP_036019 (protein)

Location

Chr 22: 40.7 - 40.72 Mb

Chr 15: 82.1 - 82.12 Mb

Pubmed search

[1]

[2]

Septin 3, also known as SEPT3, is a human gene.^[1]

This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in multiple transcript variants.^[1]

[edit] References

^ ^a ^b Entrez Gene: SEPT3 septin 3.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Methner A, Leypoldt F, Joost P, Lewerenz J (2001). "Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation.". Biochem. Biophys. Res. Commun. 283 (1): 48–56. doi:10.1006/bbrc.2001.4741. PMID 11322766.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Xue J, Milburn PJ, Hanna BT, et al. (2004). "Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals.". Biochem. J. 381 (Pt 3): 753–60. doi:10.1042/BJ20040455. PMID 15107017.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Xue J, Tsang CW, Gai WP, et al. (2005). "Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals.". J. Neurochem. 91 (3): 579–90. doi:10.1111/j.1471-4159.2004.02755.x. PMID 15485489.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.